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4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells.
Lefranc F, Xu Z, Burth P, Mathieu V, Revelant G, de Castro Faria MV, Noyon C, Garcia DG, Dufour D, Bruyère C, Gonçalves-de-Albuquerque CF, Van Antwerpen P, Rogister B, Hesse S, Kirsch G, Kiss R. Lefranc F, et al. Among authors: garcia dg. Eur J Med Chem. 2013 May;63:213-23. doi: 10.1016/j.ejmech.2013.01.046. Epub 2013 Feb 16. Eur J Med Chem. 2013. PMID: 23474907
Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol.
Garcia DG, de Castro-Faria-Neto HC, da Silva CI, de Souza e Souza KF, Gonçalves-de-Albuquerque CF, Silva AR, de Amorim LM, Freire AS, Santelli RE, Diniz LP, Gomes FC, Faria MV, Burth P. Garcia DG, et al. Mol Cancer. 2015 May 15;14:105. doi: 10.1186/s12943-015-0374-5. Mol Cancer. 2015. PMID: 25976744 Free PMC article.
Na/K-ATPase: Their role in cell adhesion and migration in cancer.
Silva CID, Gonçalves-de-Albuquerque CF, Moraes BPT, Garcia DG, Burth P. Silva CID, et al. Among authors: garcia dg. Biochimie. 2021 Jun;185:1-8. doi: 10.1016/j.biochi.2021.03.002. Epub 2021 Mar 10. Biochimie. 2021. PMID: 33713729 Free article. Review.
The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor.
Garcia DG, Amorim LM, de Castro Faria MV, Freire AS, Santelli RE, Da Fonseca CO, Quirico-Santos T, Burth P. Garcia DG, et al. Mol Cell Biochem. 2010 Dec;345(1-2):29-34. doi: 10.1007/s11010-010-0556-9. Epub 2010 Aug 6. Mol Cell Biochem. 2010. PMID: 20689980
Reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration.
Gonçalves de Albuquerque CF, Burth P, Younes Ibrahim M, Garcia DG, Bozza PT, Castro Faria Neto HC, Castro Faria MV. Gonçalves de Albuquerque CF, et al. Among authors: garcia dg. Mediators Inflamm. 2012;2012:601032. doi: 10.1155/2012/601032. Epub 2012 Feb 27. Mediators Inflamm. 2012. PMID: 22529526 Free PMC article.
Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens.
França LC, Fontes-Dantas FL, Garcia DG, de Araújo AD, da Costa Gonçalves JP, Rêgo CCDS, da Silva EV, do Nascimento OJM, Lopes FCR, Herlinger AL, de Aguiar RS, da Costa Ferreira Junior O, Figueira FFA, de Souza JPBM, De Mesquita JF, Alves-Leon SV. França LC, et al. Among authors: garcia dg. Arq Neuropsiquiatr. 2023 Apr;81(4):357-368. doi: 10.1055/s-0043-1768698. Epub 2023 May 9. Arq Neuropsiquiatr. 2023. PMID: 37160141 Free PMC article.
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