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Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties.
Fernández-Bachiller MI, Pérez C, Campillo NE, Páez JA, González-Muñoz GC, Usán P, García-Palomero E, López MG, Villarroya M, García AG, Martínez A, Rodríguez-Franco MI. Fernández-Bachiller MI, et al. Among authors: garcia palomero e. ChemMedChem. 2009 May;4(5):828-41. doi: 10.1002/cmdc.200800414. ChemMedChem. 2009. PMID: 19308922
Potent beta-amyloid modulators.
García-Palomero E, Muñoz P, Usan P, Garcia P, Delgado E, De Austria C, Valenzuela R, Rubio L, Medina M, Martínez A. García-Palomero E, et al. Neurodegener Dis. 2008;5(3-4):153-6. doi: 10.1159/000113688. Epub 2008 Mar 6. Neurodegener Dis. 2008. PMID: 18322376 Review.
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Muñoz-Ruiz P, Rubio L, García-Palomero E, Dorronsoro I, del Monte-Millán M, Valenzuela R, Usán P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M, Martínez A. Muñoz-Ruiz P, et al. Among authors: garcia palomero e. J Med Chem. 2005 Nov 17;48(23):7223-33. doi: 10.1021/jm0503289. J Med Chem. 2005. PMID: 16279781
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
Alonso D, Dorronsoro I, Rubio L, Muñoz P, García-Palomero E, Del Monte M, Bidon-Chanal A, Orozco M, Luque FJ, Castro A, Medina M, Martínez A. Alonso D, et al. Among authors: garcia palomero e. Bioorg Med Chem. 2005 Dec 15;13(24):6588-97. doi: 10.1016/j.bmc.2005.09.029. Epub 2005 Oct 17. Bioorg Med Chem. 2005. PMID: 16230018
Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers.
López MG, Montiel C, Herrero CJ, García-Palomero E, Mayorgas I, Hernández-Guijo JM, Villarroya M, Olivares R, Gandía L, McIntosh JM, Olivera BM, García AG. López MG, et al. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14184-9. doi: 10.1073/pnas.95.24.14184. Proc Natl Acad Sci U S A. 1998. PMID: 9826675 Free PMC article.
24 results