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Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore.
García-Aranda MI, Gonzalez-Padilla JE, Gómez-Castro CZ, Gómez-Gómez YM, Rosales-Hernández MC, García-Báez EV, Franco-Hernández MO, Castrejón-Flores JL, Padilla-Martínez II. García-Aranda MI, et al. Bioorg Med Chem. 2020 May 1;28(9):115427. doi: 10.1016/j.bmc.2020.115427. Epub 2020 Mar 21. Bioorg Med Chem. 2020. PMID: 32205045
Involvement of conformational isomerism in the complexity of the crystal network of 1-(4-nitrophenyl)-1H-1,3-benzimidazole derivatives driven by C-H...A (A = NO2, Npy and π) and orthogonal Npy...NO2 and ONO...Csp2 interactions.
García-Aranda MI, Gómez-Castro CZ, García-Báez EV, Gómez YGY, Castrejón-Flores JL, Padilla-Martínez II. García-Aranda MI, et al. Acta Crystallogr C Struct Chem. 2018 Apr 1;74(Pt 4):428-436. doi: 10.1107/S2053229618003406. Epub 2018 Mar 7. Acta Crystallogr C Struct Chem. 2018. PMID: 29620026 Free PMC article.
Helical peptides from VEGF and Vammin hotspots for modulating the VEGF-VEGFR interaction.
García-Aranda MI, González-López S, Santiveri CM, Gagey-Eilstein N, Reille-Seroussi M, Martín-Martínez M, Inguimbert N, Vidal M, García-López MT, Jiménez MA, González-Muñiz R, Pérez de Vega MJ. García-Aranda MI, et al. Org Biomol Chem. 2013 Mar 21;11(11):1896-905. doi: 10.1039/c3ob27312a. Epub 2013 Feb 4. Org Biomol Chem. 2013. PMID: 23381088
Disulfide and amide-bridged cyclic peptide analogues of the VEGF₈₁₋₉₁ fragment: synthesis, conformational analysis and biological evaluation.
García-Aranda MI, Mirassou Y, Gautier B, Martín-Martínez M, Inguimbert N, Vidal M, García-López MT, Jiménez MA, González-Muñiz R, Pérez de Vega MJ. García-Aranda MI, et al. Bioorg Med Chem. 2011 Dec 15;19(24):7526-33. doi: 10.1016/j.bmc.2011.10.032. Epub 2011 Oct 18. Bioorg Med Chem. 2011. PMID: 22078412
Parallel solid-phase synthesis of a small library of linear and hydrocarbon-bridged analogues of VEGF(81-91): potential biological tools for studying the VEGF/VEGFR-1 interaction.
García-Aranda MI, Marrero P, Gautier B, Martín-Martínez M, Inguimbert N, Vidal M, García-López MT, Jiménez MA, González-Muñiz R, Pérez de Vega MJ. García-Aranda MI, et al. Bioorg Med Chem. 2011 Mar 15;19(6):1978-86. doi: 10.1016/j.bmc.2011.01.056. Epub 2011 Feb 2. Bioorg Med Chem. 2011. PMID: 21349728