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Targeting glial cannabinoid CB2 receptors to delay the progression of the pathological phenotype in TDP-43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis.
Espejo-Porras F, García-Toscano L, Rodríguez-Cueto C, Santos-García I, de Lago E, Fernandez-Ruiz J. Espejo-Porras F, et al. Among authors: garcia toscano l. Br J Pharmacol. 2019 May;176(10):1585-1600. doi: 10.1111/bph.14216. Epub 2018 May 6. Br J Pharmacol. 2019. PMID: 29574689 Free PMC article.
Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1G93A transgenic mice, an experimental model of amyotrophic lateral sclerosis.
Rodríguez-Cueto C, Santos-García I, García-Toscano L, Espejo-Porras F, Bellido M, Fernández-Ruiz J, Muñoz E, de Lago E. Rodríguez-Cueto C, et al. Among authors: garcia toscano l. Biochem Pharmacol. 2018 Nov;157:217-226. doi: 10.1016/j.bcp.2018.07.049. Epub 2018 Aug 1. Biochem Pharmacol. 2018. PMID: 30076846
Targeting the CB2 receptor and other endocannabinoid elements to delay disease progression in amyotrophic lateral sclerosis.
Rodríguez-Cueto C, García-Toscano L, Santos-García I, Gómez-Almería M, Gonzalo-Consuegra C, Espejo-Porras F, Fernández-Ruiz J, de Lago E. Rodríguez-Cueto C, et al. Among authors: garcia toscano l. Br J Pharmacol. 2021 Mar;178(6):1373-1387. doi: 10.1111/bph.15386. Epub 2021 Feb 20. Br J Pharmacol. 2021. PMID: 33486755 Free article. Review.
Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1 receptor ligand antagonists.
Murineddu G, Deligia F, Ragusa G, García-Toscano L, Gómez-Cañas M, Asproni B, Satta V, Cichero E, Pazos R, Fossa P, Loriga G, Fernández-Ruiz J, Pinna GA. Murineddu G, et al. Among authors: garcia toscano l. Bioorg Med Chem. 2018 Jan 1;26(1):295-307. doi: 10.1016/j.bmc.2017.11.051. Epub 2017 Dec 2. Bioorg Med Chem. 2018. PMID: 29229226
Corrigendum to "Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile" [Pharmacol. Res. 110 (August 2016) (2016) 205-215].
Gómez-Cañas M, Morales P, García-Toscano L, Navarrete C, Muñoz E, Jagerovic N, Fernández-Ruiz J, García-Arencibia M, Pazos MR. Gómez-Cañas M, et al. Among authors: garcia toscano l. Pharmacol Res. 2017 Jun;120:302. doi: 10.1016/j.phrs.2017.04.002. Epub 2017 Apr 20. Pharmacol Res. 2017. PMID: 28433484 No abstract available.
Structure-Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives.
Götz MR, Collado JA, Fernández-Ruiz J, Fiebich BL, García-Toscano L, Gómez-Cañas M, Koch O, Leha A, Muñoz E, Navarrete C, Pazos MR, Holzgrabe U. Götz MR, et al. Among authors: garcia toscano l. Front Pharmacol. 2019 Nov 20;10:1284. doi: 10.3389/fphar.2019.01284. eCollection 2019. Front Pharmacol. 2019. PMID: 31824305 Free PMC article.
Cannabidiol Administration Prevents Hypoxia-Ischemia-Induced Hypomyelination in Newborn Rats.
Ceprián M, Vargas C, García-Toscano L, Penna F, Jiménez-Sánchez L, Achicallende S, Elezgarai I, Grandes P, Hind W, Pazos MR, Martínez-Orgado J. Ceprián M, et al. Among authors: garcia toscano l. Front Pharmacol. 2019 Sep 26;10:1131. doi: 10.3389/fphar.2019.01131. eCollection 2019. Front Pharmacol. 2019. PMID: 31611802 Free PMC article.
Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids in experimental TDP-43 related frontotemporal dementia using male mice.
Gonzalo-Consuegra C, Santos-García I, García-Toscano L, Martín-Baquero R, Rodríguez-Cueto C, Wittwer MB, Dzygiel P, Grether U, de Lago E, Fernández-Ruiz J. Gonzalo-Consuegra C, et al. Among authors: garcia toscano l. Biomed Pharmacother. 2024 May;174:116473. doi: 10.1016/j.biopha.2024.116473. Epub 2024 Mar 24. Biomed Pharmacother. 2024. PMID: 38522237 Free article.