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Hormones and diet, but not body weight, control hypothalamic microglial activity.
Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, Mergen C, Bour S, Thaler JP, Seeley RJ, Filosa J, Stern JE, Perez-Tilve D, Schwartz MW, Tschöp MH, Yi CX. Gao Y, et al. Glia. 2014 Jan;62(1):17-25. doi: 10.1002/glia.22580. Epub 2013 Oct 28. Glia. 2014. PMID: 24166765 Free PMC article.
TNFα drives mitochondrial stress in POMC neurons in obesity.
Yi CX, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, Layritz C, García-Cáceres C, Bielohuby M, Bidlingmaier M, Woods SC, Ghanem A, Conzelmann KK, Stern JE, Jastroch M, Tschöp MH. Yi CX, et al. Among authors: gao y. Nat Commun. 2017 May 10;8:15143. doi: 10.1038/ncomms15143. Nat Commun. 2017. PMID: 28489068 Free PMC article.
Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity.
Gao Y, Layritz C, Legutko B, Eichmann TO, Laperrousaz E, Moullé VS, Cruciani-Guglielmacci C, Magnan C, Luquet S, Woods SC, Eckel RH, Yi CX, Garcia-Caceres C, Tschöp MH. Gao Y, et al. Diabetes. 2017 Oct;66(10):2555-2563. doi: 10.2337/db16-1278. Epub 2017 Jul 14. Diabetes. 2017. PMID: 28710138 Free PMC article.
Dietary sugars, not lipids, drive hypothalamic inflammation.
Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX. Gao Y, et al. Mol Metab. 2017 Jun 20;6(8):897-908. doi: 10.1016/j.molmet.2017.06.008. eCollection 2017 Aug. Mol Metab. 2017. PMID: 28752053 Free PMC article.
Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity.
Gao Y, Vidal-Itriago A, Kalsbeek MJ, Layritz C, García-Cáceres C, Tom RZ, Eichmann TO, Vaz FM, Houtkooper RH, van der Wel N, Verhoeven AJ, Yan J, Kalsbeek A, Eckel RH, Hofmann SM, Yi CX. Gao Y, et al. Cell Rep. 2017 Sep 26;20(13):3034-3042. doi: 10.1016/j.celrep.2017.09.008. Cell Rep. 2017. PMID: 28954222 Free article.
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