2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance.
Gangjee A, Namjoshi OA, Keller SN, Smith CD.
Gangjee A, et al.
Bioorg Med Chem. 2011 Jul 15;19(14):4355-65. doi: 10.1016/j.bmc.2011.05.030. Epub 2011 May 23.
Bioorg Med Chem. 2011.
PMID: 21680190
Free PMC article.
Gangjee et al. recently reported a novel series of 2-amino-4-methyl-5-phenylethyl substituted-7-benzyl-pyrrolo[2,3-d]pyrimidines, some of which exhibited two digit nanomolar antitumor and antimitotic activity and were not subject to P-glycoprotein (Pgp) or multidrug …
Gangjee et al. recently reported a novel series of 2-amino-4-methyl-5-phenylethyl substituted-7-benzyl-pyrrolo[2,3-d]pyrimidin …