Gan J - Search Results

1

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Zhang D, He K, Herbst JJ, Kolb J, Shou W, Wang L, Balimane PV, Han YH, Gan J, Frost CE, Humphreys WG. Zhang D, et al. Among authors: gan j. Drug Metab Dispos. 2013 Apr;41(4):827-35. doi: 10.1124/dmd.112.050260. Epub 2013 Feb 4. Drug Metab Dispos. 2013. PMID: 23382458

2

Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.

Gu X, Wang L, Gan J, Fancher RM, Tian Y, Hong Y, Lai Y, Sinz M, Shen H. Gu X, et al. Among authors: gan j. Drug Metab Dispos. 2020 Aug;48(8):724-734. doi: 10.1124/dmd.120.090670. Epub 2020 Jun 1. Drug Metab Dispos. 2020. PMID: 32482623

3

CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183).

Zhang D, Ly VT, Lago M, Tian Y, Gan J, Humphreys WG, Cömezoglu SN. Zhang D, et al. Among authors: gan j. Drug Metab Dispos. 2009 Apr;37(4):710-8. doi: 10.1124/dmd.108.024398. Epub 2009 Jan 21. Drug Metab Dispos. 2009. PMID: 19158314

4

In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin.

Gan J, Liu-Kreyche P, Humphreys WG. Gan J, et al. Cancer Chemother Pharmacol. 2012 Jan;69(1):51-6. doi: 10.1007/s00280-011-1672-2. Epub 2011 May 19. Cancer Chemother Pharmacol. 2012. PMID: 21594721

5

Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment.

Cheng Y, Freeden C, Zhang Y, Abraham P, Shen H, Wescott D, Humphreys WG, Gan J, Lai Y. Cheng Y, et al. Among authors: gan j. Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. Biopharm Drug Dispos. 2016. PMID: 27059119

6

Drug-Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization.

Gan J, Zhang H, Humphreys WG. Gan J, et al. Chem Res Toxicol. 2016 Dec 19;29(12):2040-2057. doi: 10.1021/acs.chemrestox.6b00274. Epub 2016 Dec 5. Chem Res Toxicol. 2016. PMID: 27989144 Review.

7

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.

Shen H, Chen W, Drexler DM, Mandlekar S, Holenarsipur VK, Shields EE, Langish R, Sidik K, Gan J, Humphreys WG, Marathe P, Lai Y. Shen H, et al. Among authors: gan j. Drug Metab Dispos. 2017 Aug;45(8):908-919. doi: 10.1124/dmd.117.075531. Epub 2017 Jun 2. Drug Metab Dispos. 2017. PMID: 28576766

8

Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.

Cheng Y, Chen S, Freeden C, Chen W, Zhang Y, Abraham P, Nelson DM, Humphreys WG, Gan J, Lai Y. Cheng Y, et al. Among authors: gan j. J Pharmacol Exp Ther. 2017 Sep;362(3):385-394. doi: 10.1124/jpet.117.242370. Epub 2017 Jun 23. J Pharmacol Exp Ther. 2017. PMID: 28645914

9

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.

Shen H, Nelson DM, Oliveira RV, Zhang Y, Mcnaney CA, Gu X, Chen W, Su C, Reily MD, Shipkova PA, Gan J, Lai Y, Marathe P, Humphreys WG. Shen H, et al. Among authors: gan j. Drug Metab Dispos. 2018 Feb;46(2):178-188. doi: 10.1124/dmd.117.077586. Epub 2017 Nov 21. Drug Metab Dispos. 2018. PMID: 29162614

10

Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS).

Cömezoğlu SN, Ly VT, Zhang D, Humphreys WG, Bonacorsi SJ, Everett DW, Cohen MB, Gan J, Beumer JH, Beijnen JH, Schellens HM, Lappin G. Cömezoğlu SN, et al. Among authors: gan j. Drug Metab Pharmacokinet. 2009;24(6):511-22. doi: 10.2133/dmpk.24.511. Drug Metab Pharmacokinet. 2009. PMID: 20045986 Free article.

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