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COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history.
Townsley H, Gahir J, Russell TW, Greenwood D, Carr EJ, Dyke M, Adams L, Miah M, Clayton B, Smith C, Miranda M, Mears HV, Bailey C, Black JRM, Fowler AS, Crawford M, Wilkinson K, Hutchinson M, Harvey R, O'Reilly N, Kelly G, Goldstone R, Beale R, Papineni P, Corrah T, Gilson R, Caidan S, Nicod J, Gamblin S, Kassiotis G, Libri V, Williams B, Gandhi S, Kucharski AJ, Swanton C, Bauer DLV, Wall EC. Townsley H, et al. Among authors: gamblin s. PLoS One. 2024 Mar 21;19(3):e0294897. doi: 10.1371/journal.pone.0294897. eCollection 2024. PLoS One. 2024. PMID: 38512960 Free PMC article.
Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign.
Shawe-Taylor M, Greenwood D, Hobbs A, Dowgier G, Penn R, Sanderson T, Stevenson-Leggett P, Bazire J, Harvey R; Crick COVID Serology Pipeline Investigators, Legacy Investigators; Libri V, Kassiotis G, Gamblin S, Lewis NS, Williams B, Swanton C, Gandhi S, Carr EJ, Wu MY, Bauer DLV, Wall EC. Shawe-Taylor M, et al. Among authors: gamblin s. Lancet. 2024 Mar 23;403(10432):1133-1136. doi: 10.1016/S0140-6736(24)00316-7. Epub 2024 Mar 11. Lancet. 2024. PMID: 38484752 No abstract available.
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants.
Russell TW, Townsley H, Abbott S, Hellewell J, Carr EJ, Chapman LAC, Pung R, Quilty BJ, Hodgson D, Fowler AS, Adams L, Bailey C, Mears HV, Harvey R, Clayton B, O'Reilly N, Ngai Y, Nicod J, Gamblin S, Williams B, Gandhi S, Swanton C, Beale R, Bauer DLV, Wall EC, Kucharski AJ. Russell TW, et al. Among authors: gamblin s. PLoS Biol. 2024 Jan 30;22(1):e3002463. doi: 10.1371/journal.pbio.3002463. eCollection 2024 Jan. PLoS Biol. 2024. PMID: 38289907 Free PMC article.
SARS-CoV-2 mucosal neutralising immunity after vaccination.
Carr EJ, Dowgier G, Greenwood D, Herman LS, Hobbs A, Ragno M, Stevenson-Leggett P, Gahir J, Townsley H, Harvey R, Bailey C, Fowler AS, Miah M, Smith C, Miranda M, Bawumia P, Mears HV, Adams L, Hatipoglu E, O'Reilly N, Warchal S, Sawyer C, Ambrose K, Strange A, Kelly G, Beale R, Papineni P, Corrah T, Gilson R, Gamblin S, Kassiotis G, Libri V, Williams B, Swanton C, Gandhi S, Bauer DLV, Wall E, Wu MY. Carr EJ, et al. Among authors: gamblin s. Lancet Infect Dis. 2024 Jan;24(1):e4-e5. doi: 10.1016/S1473-3099(23)00705-3. Epub 2023 Dec 6. Lancet Infect Dis. 2024. PMID: 38070528 No abstract available.
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London.
Bailey C, Sanderson T, Townsley H, Goldman J, Black JRM, Young G, Goldstone R, Fowler AS, Ward S, Jackson DJ, Cubitt L, Dearing V, O'Neil O, Crawford M, Snell D, Finadis M, Edwards A, Perez-Lloret J, Gahir J, Carr EJ, Riddell A, Aitken J, Ambrose K, Sawyer C, O'Reilly N, Caidan S, Wu MY, Walker PA, Hindmarsh S, Howell M, Jordan A, Fleming J, Houlihan C, Nastouli E, Moores R, Hsu D, Papineni P, Corrah T, Gilson R, MacRae J, Hubank M, Van As N, Turajlic S, Beale R, Levi M; Crick COVID-19 Consortium; Barrell S, Williams B, Gamblin S, Nicod J, Gandhi S, Bauer DLV, Wall EC, Swanton C. Bailey C, et al. Among authors: gamblin s. Lancet. 2023 Jul 1;402(10395):21-24. doi: 10.1016/S0140-6736(23)00917-0. Epub 2023 Jun 19. Lancet. 2023. PMID: 37348521 Free PMC article. No abstract available.
Within-host SARS-CoV-2 viral kinetics informed by complex life course exposures reveals different intrinsic properties of Omicron and Delta variants.
Russell TW, Townsley H, Abbott S, Hellewell J, Carr EJ, Chapman L, Pung R, Quilty BJ, Hodgson D, Fowler AS, Adams L, Bailey C, Mears HV, Harvey R, Clayton B, O'Reilly N, Ngai Y, Nicod J, Gamblin S, Williams B, Gandhi S, Swanton C, Beale R, Bauer DL, Wall EC, Kucharski A. Russell TW, et al. Among authors: gamblin s. medRxiv [Preprint]. 2023 May 24:2023.05.17.23290105. doi: 10.1101/2023.05.17.23290105. medRxiv. 2023. PMID: 37292842 Free PMC article. Preprint.
Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection.
Carr EJ, Wu MY, Gahir J, Harvey R, Townsley H, Bailey C, Fowler AS, Dowgier G, Hobbs A, Herman L, Ragno M, Miah M, Bawumia P, Smith C, Miranda M, Mears HV, Adams L, Haptipoglu E, O'Reilly N, Warchal S, Sawyer C, Ambrose K, Kelly G, Beale R, Papineni P, Corrah T, Gilson R, Gamblin S, Kassiotis G, Libri V, Williams B, Swanton C, Gandhi S, Lv Bauer D, Wall EC; Crick COVID Serology Consortium. Carr EJ, et al. Among authors: gamblin s. Lancet Infect Dis. 2023 Jul;23(7):781-784. doi: 10.1016/S1473-3099(23)00289-X. Epub 2023 Jun 5. Lancet Infect Dis. 2023. PMID: 37290472 Free PMC article. No abstract available.
Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes.
Tut G, Lancaster T, Krutikov M, Sylla P, Bone D, Spalkova E, Bentley C, Amin U, Jadir A, Hulme S, Kaur N, Tut E, Bruton R, Wu MY, Harvey R, Carr EJ; Crick COVID Immunity Pipeline; Beale R, Stirrup O, Shrotri M, Azmi B, Fuller C, Baynton V, Irwin-Singer A, Hayward A, Copas A, Shallcross L, Moss P. Tut G, et al. Nat Aging. 2023 Jan;3(1):93-104. doi: 10.1038/s43587-022-00328-3. Epub 2023 Jan 20. Nat Aging. 2023. PMID: 37118525 Free PMC article.
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer.
Wu MY, Shepherd STC, Fendler A, Carr EJ, Au L, Harvey R, Dowgier G, Hobbs A, Herman LS, Ragno M, Adams L, Schmitt AM, Tippu Z, Shum B, Farag S, Rogiers A, O'Reilly N, Bawumia P, Smith C, Carlyle E, Edmonds K, Del Rosario L, Lingard K, Mangwende M, Holt L, Ahmod H, Korteweg J, Foley T, Barber T, Hepworth S, Emslie-Henry A, Caulfield-Lynch N, Byrne F, Deng D, Williams B, Brown M, Caidan S, Gavrielides M, MacRae JI, Kelly G, Peat K, Kelly D, Murra A, Kelly K, O'Flaherty M, Popat S, Yousaf N, Jhanji S, Tatham K, Cunningham D, Van As N, Young K, Furness AJS, Pickering L, Beale R, Swanton C, Gandhi S, Gamblin S, Bauer DLV, Kassiotis G, Howell M, Walker S, Nicholson E, Larkin J, Wall EC, Turajlic S; CAPTURE consortium. Wu MY, et al. Among authors: gamblin s. Cancer Cell. 2023 May 8;41(5):821-823. doi: 10.1016/j.ccell.2023.04.005. Epub 2023 Apr 13. Cancer Cell. 2023. PMID: 37116490 Free PMC article.
134 results