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Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling.
Rosenberg N, Van Haele M, Lanton T, Brashi N, Bromberg Z, Adler H, Giladi H, Peled A, Goldenberg DS, Axelrod JH, Simerzin A, Chai C, Paldor M, Markezana A, Yaish D, Shemulian Z, Gross D, Barnoy S, Gefen M, Amran O, Claerhout S, Fernández-Vaquero M, García-Beccaria M, Heide D, Shoshkes-Carmel M, Schmidt Arras D, Elgavish S, Nevo Y, Benyamini H, Tirnitz-Parker JEE, Sanchez A, Herrera B, Safadi R, Kaestner KH, Rose-John S, Roskams T, Heikenwalder M, Galun E. Rosenberg N, et al. Among authors: galun e. J Hepatol. 2022 Dec;77(6):1631-1641. doi: 10.1016/j.jhep.2022.07.029. Epub 2022 Aug 18. J Hepatol. 2022. PMID: 35988690
The regenerative activity of interleukin-6.
Galun E, Rose-John S. Galun E, et al. Methods Mol Biol. 2013;982:59-77. doi: 10.1007/978-1-62703-308-4_4. Methods Mol Biol. 2013. PMID: 23456862
Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice.
Barashi N, Weiss ID, Wald O, Wald H, Beider K, Abraham M, Klein S, Goldenberg D, Axelrod J, Pikarsky E, Abramovitch R, Zeira E, Galun E, Peled A. Barashi N, et al. Among authors: galun e. Hepatology. 2013 Sep;58(3):1021-30. doi: 10.1002/hep.26403. Epub 2013 Jul 12. Hepatology. 2013. PMID: 23526353
Interleukin 6-dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis.
Lanton T, Shriki A, Nechemia-Arbely Y, Abramovitch R, Levkovitch O, Adar R, Rosenberg N, Paldor M, Goldenberg D, Sonnenblick A, Peled A, Rose-John S, Galun E, Axelrod JH. Lanton T, et al. Among authors: galun e. Hepatology. 2017 May;65(5):1600-1611. doi: 10.1002/hep.29004. Epub 2017 Mar 23. Hepatology. 2017. PMID: 28027584
The two facets of gp130 signalling in liver tumorigenesis.
Schmidt-Arras D, Galun E, Rose-John S. Schmidt-Arras D, et al. Among authors: galun e. Semin Immunopathol. 2021 Aug;43(4):609-624. doi: 10.1007/s00281-021-00861-0. Epub 2021 May 28. Semin Immunopathol. 2021. PMID: 34047814 Free PMC article. Review.
Single-cell transcriptomics reveals a senescence-associated IL-6/CCR6 axis driving radiodermatitis.
Paldor M, Levkovitch-Siany O, Eidelshtein D, Adar R, Enk CD, Marmary Y, Elgavish S, Nevo Y, Benyamini H, Plaschkes I, Klein S, Mali A, Rose-John S, Peled A, Galun E, Axelrod JH. Paldor M, et al. Among authors: galun e. EMBO Mol Med. 2022 Aug 8;14(8):e15653. doi: 10.15252/emmm.202115653. Epub 2022 Jul 4. EMBO Mol Med. 2022. PMID: 35785521 Free PMC article.
321 results