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Ligand and Target Discovery by Fragment-Based Screening in Human Cells.
Parker CG, Galmozzi A, Wang Y, Correia BE, Sasaki K, Joslyn CM, Kim AS, Cavallaro CL, Lawrence RM, Johnson SR, Narvaiza I, Saez E, Cravatt BF. Parker CG, et al. Among authors: galmozzi a. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19. Cell. 2017. PMID: 28111073 Free PMC article.
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
Dominguez E, Galmozzi A, Chang JW, Hsu KL, Pawlak J, Li W, Godio C, Thomas J, Partida D, Niessen S, O'Brien PE, Russell AP, Watt MJ, Nomura DK, Cravatt BF, Saez E. Dominguez E, et al. Among authors: galmozzi a. Nat Chem Biol. 2014 Feb;10(2):113-21. doi: 10.1038/nchembio.1429. Epub 2013 Dec 22. Nat Chem Biol. 2014. PMID: 24362705 Free PMC article.
PGRMC2 is an intracellular haem chaperone critical for adipocyte function.
Galmozzi A, Kok BP, Kim AS, Montenegro-Burke JR, Lee JY, Spreafico R, Mosure S, Albert V, Cintron-Colon R, Godio C, Webb WR, Conti B, Solt LA, Kojetin D, Parker CG, Peluso JJ, Pru JK, Siuzdak G, Cravatt BF, Saez E. Galmozzi A, et al. Nature. 2019 Dec;576(7785):138-142. doi: 10.1038/s41586-019-1774-2. Epub 2019 Nov 20. Nature. 2019. PMID: 31748741 Free PMC article.
Discovery of small-molecule enzyme activators by activity-based protein profiling.
Kok BP, Ghimire S, Kim W, Chatterjee S, Johns T, Kitamura S, Eberhardt J, Ogasawara D, Xu J, Sukiasyan A, Kim SM, Godio C, Bittencourt JM, Cameron M, Galmozzi A, Forli S, Wolan DW, Cravatt BF, Boger DL, Saez E. Kok BP, et al. Among authors: galmozzi a. Nat Chem Biol. 2020 Sep;16(9):997-1005. doi: 10.1038/s41589-020-0555-4. Epub 2020 Jun 8. Nat Chem Biol. 2020. PMID: 32514184 Free PMC article.
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.
Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly JW. Chen W, et al. Among authors: galmozzi a. J Am Chem Soc. 2016 Jun 15;138(23):7353-64. doi: 10.1021/jacs.6b02960. Epub 2016 Jun 2. J Am Chem Soc. 2016. PMID: 27191344 Free PMC article.
Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs.
Parker CG, Kuttruff CA, Galmozzi A, Jørgensen L, Yeh CH, Hermanson DJ, Wang Y, Artola M, McKerrall SJ, Josyln CM, Nørremark B, Dünstl G, Felding J, Saez E, Baran PS, Cravatt BF. Parker CG, et al. Among authors: galmozzi a. ACS Cent Sci. 2017 Dec 27;3(12):1276-1285. doi: 10.1021/acscentsci.7b00420. Epub 2017 Dec 6. ACS Cent Sci. 2017. PMID: 29296668 Free PMC article.
39 results