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A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress.
Fedeles BI, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade DC, Westergerling P, Staudner T, Campolo J, Liu SS, Dong K, Cai Y, Rehman M, Gallagher AR, Ruchirawat S, Croy RG, Essigmann JM, Fedeles SV, Somlo S. Fedeles BI, et al. Among authors: gallagher ar. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2317344121. doi: 10.1073/pnas.2317344121. Epub 2024 Jan 19. Proc Natl Acad Sci U S A. 2024. PMID: 38241440 Free PMC article.
XBP1 Activation Reduces Severity of Polycystic Kidney Disease due to a Nontruncating Polycystin-1 Mutation in Mice.
Krappitz M, Bhardwaj R, Dong K, Staudner T, Yilmaz DE, Pioppini C, Westergerling P, Ruemmele D, Hollmann T, Nguyen TA, Cai Y, Gallagher AR, Somlo S, Fedeles S. Krappitz M, et al. Among authors: gallagher ar. J Am Soc Nephrol. 2023 Jan 1;34(1):110-121. doi: 10.1681/ASN.2021091180. Epub 2022 Oct 21. J Am Soc Nephrol. 2023. PMID: 36270750 Free PMC article.
36 results