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Lysyl oxidase (LOX) in vascular remodelling. Insight from a new animal model.
Orriols M, Guadall A, Galán M, Martí-Pàmies I, Varona S, Rodríguez-Calvo R, Briones AM, Navarro MA, de Diego A, Osada J, Martínez-González J, Rodríguez C. Orriols M, et al. Among authors: galan m. Thromb Haemost. 2014 Oct;112(4):812-24. doi: 10.1160/TH14-01-0024. Epub 2014 Jul 3. Thromb Haemost. 2014. PMID: 24990180
The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats.
Miana M, Galán M, Martínez-Martínez E, Varona S, Jurado-López R, Bausa-Miranda B, Antequera A, Luaces M, Martínez-González J, Rodríguez C, Cachofeiro V. Miana M, et al. Among authors: galan m. Dis Model Mech. 2015 Jun;8(6):543-51. doi: 10.1242/dmm.020107. Epub 2015 Apr 7. Dis Model Mech. 2015. PMID: 26035864 Free PMC article.
The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin profibrotic effects and ameliorates cardiovascular remodeling in diet-induced obesity in rats.
Martínez-Martínez E, Rodríguez C, Galán M, Miana M, Jurado-López R, Bartolomé MV, Luaces M, Islas F, Martínez-González J, López-Andrés N, Cachofeiro V. Martínez-Martínez E, et al. Among authors: galan m. J Mol Cell Cardiol. 2016 Mar;92:96-104. doi: 10.1016/j.yjmcc.2016.01.012. Epub 2016 Jan 15. J Mol Cell Cardiol. 2016. PMID: 26780438
Lysyl oxidase overexpression accelerates cardiac remodeling and aggravates angiotensin II-induced hypertrophy.
Galán M, Varona S, Guadall A, Orriols M, Navas M, Aguiló S, de Diego A, Navarro MA, García-Dorado D, Rodríguez-Sinovas A, Martínez-González J, Rodriguez C. Galán M, et al. FASEB J. 2017 Sep;31(9):3787-3799. doi: 10.1096/fj.201601157RR. Epub 2017 May 18. FASEB J. 2017. PMID: 28522596
Our findings suggest that LOX induces an age-dependent disturbance of diastolic function and aggravates Ang II-induced hypertrophy, which provides novel insights into the role of LOX in cardiac performance.-Galan, M., Varona, S., Guadall, A., Orriols, M., Nav …
Our findings suggest that LOX induces an age-dependent disturbance of diastolic function and aggravates Ang II-induced hypertrophy, which pr …
446 results