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Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI.
Kearney KJ, Butler J, Posada OM, Wilson C, Heal S, Ali M, Hardy L, Ahnström J, Gailani D, Foster R, Hethershaw E, Longstaff C, Philippou H. Kearney KJ, et al. Among authors: gailani d. Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2014810118. doi: 10.1073/pnas.2014810118. Proc Natl Acad Sci U S A. 2021. PMID: 33397811 Free PMC article.
Activation of factor XI by products of prothrombin activation.
Matafonov A, Sarilla S, Sun MF, Sheehan JP, Serebrov V, Verhamme IM, Gailani D. Matafonov A, et al. Among authors: gailani d. Blood. 2011 Jul 14;118(2):437-45. doi: 10.1182/blood-2010-10-312983. Epub 2011 Apr 28. Blood. 2011. PMID: 21527525 Free PMC article.
A cofactor for factor XI activation.
Gailani D. Gailani D. Blood. 2011 Dec 22;118(26):6730-1. doi: 10.1182/blood-2011-10-385336. Blood. 2011. PMID: 22194395 Free article. No abstract available.
The dimeric structure of factor XI and zymogen activation.
Geng Y, Verhamme IM, Smith SB, Sun MF, Matafonov A, Cheng Q, Smith SA, Morrissey JH, Gailani D. Geng Y, et al. Among authors: gailani d. Blood. 2013 May 9;121(19):3962-9. doi: 10.1182/blood-2012-12-473629. Epub 2013 Mar 20. Blood. 2013. PMID: 23515926 Free PMC article.
Factor XII inhibition reduces thrombus formation in a primate thrombosis model.
Matafonov A, Leung PY, Gailani AE, Grach SL, Puy C, Cheng Q, Sun MF, McCarty OJ, Tucker EI, Kataoka H, Renné T, Morrissey JH, Gruber A, Gailani D. Matafonov A, et al. Among authors: gailani d, gailani ae. Blood. 2014 Mar 13;123(11):1739-46. doi: 10.1182/blood-2013-04-499111. Epub 2014 Jan 9. Blood. 2014. PMID: 24408325 Free PMC article.
Why factor XI deficiency is a clinical concern.
Wheeler AP, Gailani D. Wheeler AP, et al. Among authors: gailani d. Expert Rev Hematol. 2016 Jul;9(7):629-37. doi: 10.1080/17474086.2016.1191944. Epub 2016 Jun 24. Expert Rev Hematol. 2016. PMID: 27216469 Free PMC article. Review.
An update on factor XI structure and function.
Mohammed BM, Matafonov A, Ivanov I, Sun MF, Cheng Q, Dickeson SK, Li C, Sun D, Verhamme IM, Emsley J, Gailani D. Mohammed BM, et al. Among authors: gailani d. Thromb Res. 2018 Jan;161:94-105. doi: 10.1016/j.thromres.2017.10.008. Epub 2017 Oct 10. Thromb Res. 2018. PMID: 29223926 Free PMC article. Review.
Toward a better understanding of factor XI activation.
Gailani D, Emsley J. Gailani D, et al. J Thromb Haemost. 2019 Dec;17(12):2016-2018. doi: 10.1111/jth.14631. J Thromb Haemost. 2019. PMID: 31797540 Free PMC article. No abstract available.
214 results