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T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19.
Zonozi R, Walters LC, Shulkin A, Naranbhai V, Nithagon P, Sauvage G, Kaeske C, Cosgrove K, Nathan A, Tano-Menka R, Gayton AC, Getz MA, Senjobe F, Worrall D, Iafrate AJ, Fromson C, Montesi SB, Rao DA, Sparks JA, Wallace ZS, Farmer JR, Walker BD, Charles RC, Laliberte K, Niles JL, Gaiha GD. Zonozi R, et al. Among authors: gaiha gd. Sci Transl Med. 2023 Nov 29;15(724):eadh4529. doi: 10.1126/scitranslmed.adh4529. Epub 2023 Nov 29. Sci Transl Med. 2023. PMID: 38019932
Reactivation of latent HIV-1 by inhibition of BRD4.
Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL. Zhu J, et al. Among authors: gaiha gd. Cell Rep. 2012 Oct 25;2(4):807-16. doi: 10.1016/j.celrep.2012.09.008. Epub 2012 Oct 4. Cell Rep. 2012. PMID: 23041316 Free PMC article.
Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis.
Gaiha GD, McKim KJ, Woods M, Pertel T, Rohrbach J, Barteneva N, Chin CR, Liu D, Soghoian DZ, Cesa K, Wilton S, Waring MT, Chicoine A, Doering T, Wherry EJ, Kaufmann DE, Lichterfeld M, Brass AL, Walker BD. Gaiha GD, et al. Immunity. 2014 Dec 18;41(6):1001-12. doi: 10.1016/j.immuni.2014.12.011. Epub 2014 Dec 8. Immunity. 2014. PMID: 25526311 Free PMC article.
CD8(+) T Cells and cART: A Dynamic Duo?
Gaiha GD, Walker BD. Gaiha GD, et al. Immunity. 2016 Sep 20;45(3):466-468. doi: 10.1016/j.immuni.2016.09.003. Immunity. 2016. PMID: 27653598 Free article. Review.
Structural topology defines protective CD8+ T cell epitopes in the HIV proteome.
Gaiha GD, Rossin EJ, Urbach J, Landeros C, Collins DR, Nwonu C, Muzhingi I, Anahtar MN, Waring OM, Piechocka-Trocha A, Waring M, Worrall DP, Ghebremichael MS, Newman RM, Power KA, Allen TM, Chodosh J, Walker BD. Gaiha GD, et al. Science. 2019 May 3;364(6439):480-484. doi: 10.1126/science.aav5095. Science. 2019. PMID: 31048489 Free PMC article.
CD8+ T cells in HIV control, cure and prevention.
Collins DR, Gaiha GD, Walker BD. Collins DR, et al. Among authors: gaiha gd. Nat Rev Immunol. 2020 Aug;20(8):471-482. doi: 10.1038/s41577-020-0274-9. Epub 2020 Feb 12. Nat Rev Immunol. 2020. PMID: 32051540 Free PMC article. Review.
Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.
Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, Solomon IH, Kuo HH, Boucau J, Bowman K, Adhikari UD, Winkler ML, Mueller AA, Hsu TY, Desjardins M, Baden LR, Chan BT, Walker BD, Lichterfeld M, Brigl M, Kwon DS, Kanjilal S, Richardson ET, Jonsson AH, Alter G, Barczak AK, Hanage WP, Yu XG, Gaiha GD, Seaman MS, Cernadas M, Li JZ. Choi B, et al. Among authors: gaiha gd. N Engl J Med. 2020 Dec 3;383(23):2291-2293. doi: 10.1056/NEJMc2031364. Epub 2020 Nov 11. N Engl J Med. 2020. PMID: 33176080 Free PMC article. No abstract available.
Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes.
Garcia-Bates TM, Palma ML, Anderko RR, Hsu DC, Ananworanich J, Korber BT, Gaiha GD, Phanuphak N, Thomas R, Tovanabutra S, Walker BD, Mellors JW, Piazza PA, Kroon E, Riddler SA, Michael NL, Rinaldo CR, Mailliard RB; I4C and RV254 Study Groups. Garcia-Bates TM, et al. Among authors: gaiha gd. EBioMedicine. 2021 Jan;63:103175. doi: 10.1016/j.ebiom.2020.103175. Epub 2021 Jan 12. EBioMedicine. 2021. PMID: 33450518 Free PMC article.
Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19.
Kaneko N, Boucau J, Kuo HH, Perugino C, Mahajan VS, Farmer JR, Liu H, Diefenbach TJ, Piechocka-Trocha A, Lefteri K, Waring MT, Premo KR, Walker BD, Li JZ, Gaiha G, Yu XG, Lichterfeld M, Padera RF, Pillai S. Kaneko N, et al. medRxiv [Preprint]. 2021 Mar 26:2021.03.23.21253885. doi: 10.1101/2021.03.23.21253885. medRxiv. 2021. PMID: 33791730 Free PMC article. Updated. Preprint.
38 results