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A general calculus of fitness landscapes finds genes under selection in cancers.
Genome Res. 2022 May;32(5):916-929. doi: 10.1101/gr.275811.121. Epub 2022 Mar 17.
Genome Res. 2022.
PMID: 35301263
Free PMC article.
CDKN2A/p16 Deletion in Head and Neck Cancer Cells Is Associated with CDK2 Activation, Replication Stress, and Vulnerability to CHK1 Inhibition.
Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, Redwood AB, Piwnica-Worms H, Schlacher K, Frederick MJ, Myers JN.
Gadhikar MA, et al.
Cancer Res. 2018 Feb 1;78(3):781-797. doi: 10.1158/0008-5472.CAN-17-2802. Epub 2017 Dec 11.
Cancer Res. 2018.
PMID: 29229598
Free PMC article.
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Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53.
Gadhikar MA, Sciuto MR, Alves MV, Pickering CR, Osman AA, Neskey DM, Zhao M, Fitzgerald AL, Myers JN, Frederick MJ.
Gadhikar MA, et al.
Mol Cancer Ther. 2013 Sep;12(9):1860-73. doi: 10.1158/1535-7163.MCT-13-0157. Epub 2013 Jul 9.
Mol Cancer Ther. 2013.
PMID: 23839309
Free PMC article.
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Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples.
Frederick MJ, VanMeter AJ, Gadhikar MA, Henderson YC, Yao H, Pickering CC, Williams MD, El-Naggar AK, Sandulache V, Tarco E, Myers JN, Clayman GL, Liotta LA, Petricoin EF 3rd, Calvert VS, Fodale V, Wang J, Weber RS.
Frederick MJ, et al. Among authors: gadhikar ma.
Am J Pathol. 2011 Feb;178(2):548-71. doi: 10.1016/j.ajpath.2010.10.044.
Am J Pathol. 2011.
PMID: 21281788
Free PMC article.
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Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response.
Zhao M, Wang T, Gleber-Netto FO, Chen Z, McGrail DJ, Gomez JA, Ju W, Gadhikar MA, Ma W, Shen L, Wang Q, Tang X, Pathak S, Raso MG, Burks JK, Lin SY, Wang J, Multani AS, Pickering CR, Chen J, Myers JN, Zhou G.
Zhao M, et al. Among authors: gadhikar ma.
Nat Commun. 2024 Jan 2;15(1):180. doi: 10.1038/s41467-023-44239-2.
Nat Commun. 2024.
PMID: 38167338
Free PMC article.
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