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Mechanistic studies of choline oxidase with betaine aldehyde and its isosteric analogue 3,3-dimethylbutyraldehyde.
Fan F, Germann MW, Gadda G. Fan F, et al. Among authors: gadda g. Biochemistry. 2006 Feb 14;45(6):1979-86. doi: 10.1021/bi0517537. Biochemistry. 2006. PMID: 16460045
The chemical mechanism for the oxidation of choline catalyzed by choline oxidase was recently elucidated by using kinetic isotope effects [Fan, F., and Gadda, G. (2005) J. Am. Chem. Soc. 127, 2067-2074]. In this study, the oxidation of betaine aldehyde has been inve …
The chemical mechanism for the oxidation of choline catalyzed by choline oxidase was recently elucidated by using kinetic isotope effects [F …
On the role of histidine 351 in the reaction of alcohol oxidation catalyzed by choline oxidase.
Rungsrisuriyachai K, Gadda G. Rungsrisuriyachai K, et al. Among authors: gadda g. Biochemistry. 2008 Jul 1;47(26):6762-9. doi: 10.1021/bi800650w. Epub 2008 Jun 10. Biochemistry. 2008. PMID: 18540638
The recent determination of the crystal structure of choline oxidase to a resolution of 1.86 A established the presence of two histidine residues in the active site, which may participate in catalysis. His466 was the subject of a previous study [Ghanem, M., and Gadda, G …
The recent determination of the crystal structure of choline oxidase to a resolution of 1.86 A established the presence of two histidine res …
157 results