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A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia.
Oncotarget. 2018 Mar 30;9(24):16917-16931. doi: 10.18632/oncotarget.24747. eCollection 2018 Mar 30.
Oncotarget. 2018.
PMID: 29682194
Free PMC article.
SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains.
Rzymski T, Mikula M, Żyłkiewicz E, Dreas A, Wiklik K, Gołas A, Wójcik K, Masiejczyk M, Wróbel A, Dolata I, Kitlińska A, Statkiewicz M, Kuklinska U, Goryca K, Sapała Ł, Grochowska A, Cabaj A, Szajewska-Skuta M, Gabor-Worwa E, Kucwaj K, Białas A, Radzimierski A, Combik M, Woyciechowski J, Mikulski M, Windak R, Ostrowski J, Brzózka K.
Rzymski T, et al. Among authors: gabor worwa e.
Oncotarget. 2017 May 16;8(20):33779-33795. doi: 10.18632/oncotarget.16810.
Oncotarget. 2017.
PMID: 28422713
Free PMC article.
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Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock.
Dreas A, Kucwaj-Brysz K, Pyziak K, Kulesza U, Wincza E, Fabritius CH, Michalik K, Gabor-Worwa E, Gołas A, Milik M, Masiejczyk M, Majewska E, Pyśniak K, Wójcik-Trechcińska U, Sandowska-Markiewicz Z, Brzózka K, Ostrowski J, Rzymski T, Mikula M.
Dreas A, et al. Among authors: gabor worwa e.
Eur J Med Chem. 2021 Mar 5;213:113057. doi: 10.1016/j.ejmech.2020.113057. Epub 2020 Dec 1.
Eur J Med Chem. 2021.
PMID: 33303237
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Uridine 5'-Diphospho-glucuronosyltransferase 1A3 (UGT1A3) Prediction of Hepatic Clearance of Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Substrate Telmisartan by Glucuronidation Using In Vitro-In Vivo Extrapolation (IVIVE).
Gabor-Worwa E, Kowal-Chwast A, Gaud N, Gogola D, Littlewood P, Smoluch M, Brzózka K, Kus K.
Gabor-Worwa E, et al.
Eur J Drug Metab Pharmacokinet. 2024 May;49(3):393-403. doi: 10.1007/s13318-024-00895-3. Epub 2024 Apr 20.
Eur J Drug Metab Pharmacokinet. 2024.
PMID: 38642299
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Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran.
Kowal-Chwast A, Gabor-Worwa E, Gaud N, Gogola D, Piątek A, Zarębski A, Littlewood P, Smoluch M, Brzózka K, Kuś K.
Kowal-Chwast A, et al. Among authors: gabor worwa e.
Pharmacol Rep. 2024 Apr;76(2):400-415. doi: 10.1007/s43440-024-00583-8. Epub 2024 Mar 26.
Pharmacol Rep. 2024.
PMID: 38530582
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