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LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes.
Elayyan J, Lee EJ, Gabay O, Smith CA, Qiq O, Reich E, Mobasheri A, Henrotin Y, Kimber SJ, Dvir-Ginzberg M. Elayyan J, et al. Among authors: gabay o. FASEB J. 2017 Jul;31(7):3116-3125. doi: 10.1096/fj.201601253R. Epub 2017 Apr 7. FASEB J. 2017. PMID: 28389425 Free article.
Thus, demonstrating for the first time that SIRT1 represses MMP13 in human OA chondrocytes, which appears to be mediated, at least in part, through repression of the transcription factor LEF1, a known modulator of MMP13 gene expression.-Elayyan, J., Lee, E.-J., Gabay, O …
Thus, demonstrating for the first time that SIRT1 represses MMP13 in human OA chondrocytes, which appears to be mediated, at least in part, …
Sirt1-deficient mice exhibit an altered cartilage phenotype.
Gabay O, Zaal KJ, Sanchez C, Dvir-Ginzberg M, Gagarina V, Song Y, He XH, McBurney MW. Gabay O, et al. Joint Bone Spine. 2013 Dec;80(6):613-20. doi: 10.1016/j.jbspin.2013.01.001. Epub 2013 Apr 13. Joint Bone Spine. 2013. PMID: 23587642 Free PMC article.
Osteoblast: a cell under compression.
Sanchez C, Gabay O, Henrotin YE, Berenbaum F. Sanchez C, et al. Among authors: gabay o. Biomed Mater Eng. 2008;18(4-5):221-4. Biomed Mater Eng. 2008. PMID: 19065025 Review. No abstract available.
36 results