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LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency.
O'Connor MN, Kallenberg DM, Camilli C, Pilotti C, Dritsoula A, Jackstadt R, Bowers CE, Watson HA, Alatsatianos M, Ohme J, Dowsett L, George J, Blackburn JWD, Wang X, Singhal M, Augustin HG, Ager A, Sansom OJ, Moss SE, Greenwood J. O'Connor MN, et al. Med. 2021 Nov 12;2(11):1231-1252.e10. doi: 10.1016/j.medj.2021.10.002. Epub 2021 Nov 3. Med. 2021. PMID: 35590198 Free PMC article.
LRG1: an emerging player in disease pathogenesis.
Camilli C, Hoeh AE, De Rossi G, Moss SE, Greenwood J. Camilli C, et al. J Biomed Sci. 2022 Jan 21;29(1):6. doi: 10.1186/s12929-022-00790-6. J Biomed Sci. 2022. PMID: 35062948 Free PMC article. Review.
LRG1 as a novel therapeutic target in eye disease.
De Rossi G, Da Vitoria Lobo ME, Greenwood J, Moss SE. De Rossi G, et al. Eye (Lond). 2022 Feb;36(2):328-340. doi: 10.1038/s41433-021-01807-4. Epub 2022 Jan 5. Eye (Lond). 2022. PMID: 34987199 Free PMC article. Review.
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.
Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Tripathi VB, Luhmann UFO, Lange CAK, Zhai Z, Arthur HM, Bainbridge J, Moss SE, Greenwood J. Wang X, et al. Nature. 2013 Jul 18;499(7458):306-11. doi: 10.1038/nature12345. Nature. 2013. PMID: 23868260 Free PMC article.