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OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.
Gwyer Findlay E, Danks L, Madden J, Cavanagh MM, McNamee K, McCann F, Snelgrove RJ, Shaw S, Feldmann M, Taylor PC, Horwood NJ, Hussell T. Gwyer Findlay E, et al. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2289-94. doi: 10.1073/pnas.1321071111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469824 Free PMC article.
Activated invariant NKT cells regulate osteoclast development and function.
Hu M, Bassett JH, Danks L, Howell PG, Xu K, Spanoudakis E, Kotsianidis I, Boyde A, Williams GR, Horwood N, Roberts IA, Karadimitris A. Hu M, et al. J Immunol. 2011 Mar 1;186(5):2910-7. doi: 10.4049/jimmunol.1002353. Epub 2011 Jan 28. J Immunol. 2011. PMID: 21278350
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