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Page 1
Inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and attenuates atherosclerosis and obesity in mice.
Voisin M, Shrestha E, Rollet C, Nikain CA, Josefs T, Mahé M, Barrett TJ, Chang HR, Ruoff R, Schneider JA, Garabedian ML, Zoumadakis C, Yun C, Badwan B, Brown EJ, Mar AC, Schneider RJ, Goldberg IJ, Pineda-Torra I, Fisher EA, Garabedian MJ. Voisin M, et al. Commun Biol. 2021 Mar 26;4(1):420. doi: 10.1038/s42003-021-01925-5. Commun Biol. 2021. PMID: 33772096 Free PMC article.
Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease.
Becares N, Gage MC, Voisin M, Shrestha E, Martin-Gutierrez L, Liang N, Louie R, Pourcet B, Pello OM, Luong TV, Goñi S, Pichardo-Almarza C, Røberg-Larsen H, Diaz-Zuccarini V, Steffensen KR, O'Brien A, Garabedian MJ, Rombouts K, Treuter E, Pineda-Torra I. Becares N, et al. Cell Rep. 2019 Jan 22;26(4):984-995.e6. doi: 10.1016/j.celrep.2018.12.094. Cell Rep. 2019. PMID: 30673619 Free PMC article.
Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.
Gage MC, Bécares N, Louie R, Waddington KE, Zhang Y, Tittanegro TH, Rodríguez-Lorenzo S, Jathanna A, Pourcet B, Pello OM, De la Rosa JV, Castrillo A, Pineda-Torra I. Gage MC, et al. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6556-E6565. doi: 10.1073/pnas.1721245115. Epub 2018 Jun 27. Proc Natl Acad Sci U S A. 2018. PMID: 29950315 Free PMC article.
15 results