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Page 1
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB, Chang D, Bailey P, Scarpa A, Lawlor R, Chelala C, Keyse SM, Biankin A, Morton JP, Evans TJ, Barry ST, Sansom OJ, Kocher HM, Marshall JF. Reader CS, et al. J Pathol. 2019 Nov;249(3):332-342. doi: 10.1002/path.5320. Epub 2019 Jul 30. J Pathol. 2019. PMID: 31259422 Free PMC article.
Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells.
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A, Costa-Guerra JA, Violette S, Itamochi H, Ghaem-Maghami S, Vallath S, Marshall JF, Maher J. Whilding LM, et al. Mol Ther. 2017 Oct 4;25(10):2427. doi: 10.1016/j.ymthe.2017.09.018. Epub 2017 Sep 23. Mol Ther. 2017. PMID: 28958577 Free PMC article. No abstract available.
Integrins as Therapeutic Targets: Successes and Cancers.
Raab-Westphal S, Marshall JF, Goodman SL. Raab-Westphal S, et al. Cancers (Basel). 2017 Aug 23;9(9):110. doi: 10.3390/cancers9090110. Cancers (Basel). 2017. PMID: 28832494 Free PMC article. Review.
Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M, McGrath JA, Cerio R, Kivisaari A, Kähäri VM, Hodivala-Dilke K, Brennan CH, Chen M, Marshall JF, O'Toole EA. Martins VL, et al. J Natl Cancer Inst. 2015 Oct 16;108(1):djv293. doi: 10.1093/jnci/djv293. Print 2016 Jan. J Natl Cancer Inst. 2015. PMID: 26476432
Therapeutic targeting of integrin αvβ6 in breast cancer.
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR, Haider S, Brouilette K, Saha A, Vallath S, Bowen R, Chelala C, Eccles D, Tapper WJ, Thompson AM, Quinlan P, Jordan L, Gillett C, Brentnall A, Violette S, Weinreb PH, Kendrew J, Barry ST, Hart IR, Jones JL, Marshall JF. Moore KM, et al. J Natl Cancer Inst. 2014 Jun 28;106(8):dju169. doi: 10.1093/jnci/dju169. Print 2014 Aug. J Natl Cancer Inst. 2014. PMID: 24974129 Free PMC article.
A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo.
Eberlein C, Kendrew J, McDaid K, Alfred A, Kang JS, Jacobs VN, Ross SJ, Rooney C, Smith NR, Rinkenberger J, Cao A, Churchman A, Marshall JF, Weir HM, Bedian V, Blakey DC, Foltz IN, Barry ST. Eberlein C, et al. Oncogene. 2013 Sep 12;32(37):4406-16. doi: 10.1038/onc.2012.460. Epub 2012 Oct 29. Oncogene. 2013. PMID: 23108397
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