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Extensive germline genome engineering in pigs.
Yue Y, Xu W, Kan Y, Zhao HY, Zhou Y, Song X, Wu J, Xiong J, Goswami D, Yang M, Lamriben L, Xu M, Zhang Q, Luo Y, Guo J, Mao S, Jiao D, Nguyen TD, Li Z, Layer JV, Li M, Paragas V, Youd ME, Sun Z, Ding Y, Wang W, Dou H, Song L, Wang X, Le L, Fang X, George H, Anand R, Wang SY, Westlin WF, Güell M, Markmann J, Qin W, Gao Y, Wei HJ, Church GM, Yang L. Yue Y, et al. Among authors: guell m. Nat Biomed Eng. 2021 Feb;5(2):134-143. doi: 10.1038/s41551-020-00613-9. Epub 2020 Sep 21. Nat Biomed Eng. 2021. PMID: 32958897
RNA-guided human genome engineering via Cas9.
Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM. Mali P, et al. Among authors: guell m. Science. 2013 Feb 15;339(6121):823-6. doi: 10.1126/science.1232033. Epub 2013 Jan 3. Science. 2013. PMID: 23287722 Free PMC article.
Optimization of scarless human stem cell genome editing.
Yang L, Guell M, Byrne S, Yang JL, De Los Angeles A, Mali P, Aach J, Kim-Kiselak C, Briggs AW, Rios X, Huang PY, Daley G, Church G. Yang L, et al. Among authors: guell m. Nucleic Acids Res. 2013 Oct;41(19):9049-61. doi: 10.1093/nar/gkt555. Epub 2013 Jul 31. Nucleic Acids Res. 2013. PMID: 23907390 Free PMC article.
Genome-wide inactivation of porcine endogenous retroviruses (PERVs).
Yang L, Güell M, Niu D, George H, Lesha E, Grishin D, Aach J, Shrock E, Xu W, Poci J, Cortazio R, Wilkinson RA, Fishman JA, Church G. Yang L, et al. Among authors: guell m. Science. 2015 Nov 27;350(6264):1101-4. doi: 10.1126/science.aad1191. Epub 2015 Oct 11. Science. 2015. PMID: 26456528
Engineering and optimising deaminase fusions for genome editing.
Yang L, Briggs AW, Chew WL, Mali P, Guell M, Aach J, Goodman DB, Cox D, Kan Y, Lesha E, Soundararajan V, Zhang F, Church G. Yang L, et al. Among authors: guell m. Nat Commun. 2016 Nov 2;7:13330. doi: 10.1038/ncomms13330. Nat Commun. 2016. PMID: 27804970 Free PMC article.
Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9.
Niu D, Wei HJ, Lin L, George H, Wang T, Lee IH, Zhao HY, Wang Y, Kan Y, Shrock E, Lesha E, Wang G, Luo Y, Qing Y, Jiao D, Zhao H, Zhou X, Wang S, Wei H, Güell M, Church GM, Yang L. Niu D, et al. Among authors: guell m. Science. 2017 Sep 22;357(6357):1303-1307. doi: 10.1126/science.aan4187. Epub 2017 Aug 10. Science. 2017. PMID: 28798043 Free PMC article.
91 results