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Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression.
Gómez-Sánchez R, Gegg ME, Bravo-San Pedro JM, Niso-Santano M, Alvarez-Erviti L, Pizarro-Estrella E, Gutiérrez-Martín Y, Alvarez-Barrientos A, Fuentes JM, González-Polo RA, Schapira AH. Gómez-Sánchez R, et al. Neurobiol Dis. 2014 Feb;62:426-40. doi: 10.1016/j.nbd.2013.10.021. Epub 2013 Oct 29. Neurobiol Dis. 2014. PMID: 24184327 Free PMC article.
Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson's Disease.
Rodríguez-Arribas M, Yakhine-Diop SMS, Pedro JMB, Gómez-Suaga P, Gómez-Sánchez R, Martínez-Chacón G, Fuentes JM, González-Polo RA, Niso-Santano M. Rodríguez-Arribas M, et al. Mol Neurobiol. 2017 Oct;54(8):6287-6303. doi: 10.1007/s12035-016-0140-8. Epub 2016 Oct 6. Mol Neurobiol. 2017. PMID: 27714635 Review.
Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis.
Niso-Santano M, González-Polo RA, Bravo-San Pedro JM, Gómez-Sánchez R, Lastres-Becker I, Ortiz-Ortiz MA, Soler G, Morán JM, Cuadrado A, Fuentes JM; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED). Niso-Santano M, et al. Free Radic Biol Med. 2010 May 15;48(10):1370-81. doi: 10.1016/j.freeradbiomed.2010.02.024. Epub 2010 Mar 2. Free Radic Biol Med. 2010. PMID: 20202476
DJ-1 as a modulator of autophagy: an hypothesis.
González-Polo RA, Niso-Santano M, Gómez-Sánchez R, Bravo-San Pedro JM, Fuentes JM. González-Polo RA, et al. ScientificWorldJournal. 2010 Aug 17;10:1574-9. doi: 10.1100/tsw.2010.165. ScientificWorldJournal. 2010. PMID: 20730377 Free PMC article.
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway.
Bravo-San Pedro JM, Niso-Santano M, Gómez-Sánchez R, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Bravo-San Pedro JM, et al. Cell Mol Life Sci. 2013 Jan;70(1):121-36. doi: 10.1007/s00018-012-1061-y. Epub 2012 Jul 8. Cell Mol Life Sci. 2013. PMID: 22773119
The MAPK1/3 pathway is essential for the deregulation of autophagy observed in G2019S LRRK2 mutant fibroblasts.
Bravo-San Pedro JM, Gómez-Sánchez R, Niso-Santano M, Pizarro-Estrella E, Aiastui-Pujana A, Gorostidi A, Climent V, López de Maturana R, Sanchez-Pernaute R, López de Munain A, Fuentes JM, González-Polo RA. Bravo-San Pedro JM, et al. Autophagy. 2012 Oct;8(10):1537-9. doi: 10.4161/auto.21270. Epub 2012 Aug 23. Autophagy. 2012. PMID: 22914360 Free PMC article.
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