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3-H-[1,2]Dithiole as a New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies.
Couto M, Sánchez C, Dávila B, Machín V, Varela J, Álvarez G, Cabrera M, Celano L, Aguirre-López B, Cabrera N, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Cerecetto H, González M. Couto M, et al. Among authors: gomez puyou a. Molecules. 2015 Aug 12;20(8):14595-610. doi: 10.3390/molecules200814595. Molecules. 2015. PMID: 26274947 Free PMC article.
Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.
Alvarez G, Aguirre-López B, Varela J, Cabrera M, Merlino A, López GV, Lavaggi ML, Porcal W, Di Maio R, González M, Cerecetto H, Cabrera N, Pérez-Montfort R, de Gómez-Puyou MT, Gómez-Puyou A. Alvarez G, et al. Eur J Med Chem. 2010 Dec;45(12):5767-72. doi: 10.1016/j.ejmech.2010.09.034. Epub 2010 Sep 19. Eur J Med Chem. 2010. PMID: 20889239
New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.
Alvarez G, Martínez J, Aguirre-López B, Cabrera N, Pérez-Díaz L, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Garat B, Merlino A, González M, Cerecetto H. Alvarez G, et al. Among authors: gomez puyou a. J Enzyme Inhib Med Chem. 2014 Apr;29(2):198-204. doi: 10.3109/14756366.2013.765415. Epub 2013 Feb 13. J Enzyme Inhib Med Chem. 2014. PMID: 23406473
Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non-mutagenic agents that are active in vivo.
Álvarez G, Martínez J, Varela J, Birriel E, Cruces E, Gabay M, Leal SM, Escobar P, Aguirre-López B, Cabrera N, Tuena de Gómez-Puyou M, Gómez Puyou A, Pérez-Montfort R, Yaluff G, Torres S, Serna E, Vera de Bilbao N, González M, Cerecetto H. Álvarez G, et al. Among authors: gomez puyou a. Eur J Med Chem. 2015 Jul 15;100:246-56. doi: 10.1016/j.ejmech.2015.06.018. Epub 2015 Jun 12. Eur J Med Chem. 2015. PMID: 26094151
Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity.
Aguilera E, Varela J, Birriel E, Serna E, Torres S, Yaluff G, de Bilbao NV, Aguirre-López B, Cabrera N, Díaz Mazariegos S, de Gómez-Puyou MT, Gómez-Puyou A, Pérez-Montfort R, Minini L, Merlino A, Cerecetto H, González M, Alvarez G. Aguilera E, et al. Among authors: gomez puyou a. ChemMedChem. 2016 Jun 20;11(12):1328-38. doi: 10.1002/cmdc.201500385. Epub 2015 Oct 23. ChemMedChem. 2016. PMID: 26492824
Highly specific inactivation of triosephosphate isomerase from Trypanosoma cruzi.
Téllez-Valencia A, Avila-Ríos S, Pérez-Montfort R, Rodríguez-Romero A, Tuena de Gómez-Puyou M, López-Calahorra F, Gómez-Puyou A. Téllez-Valencia A, et al. Biochem Biophys Res Commun. 2002 Jul 26;295(4):958-63. doi: 10.1016/s0006-291x(02)00796-9. Biochem Biophys Res Commun. 2002. PMID: 12127988
136 results