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Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor.
J Med Chem. 2019 Nov 14;62(21):9488-9520. doi: 10.1021/acs.jmedchem.9b00864. Epub 2019 Oct 23.
J Med Chem. 2019.
PMID: 31580666
A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.
Fyfe TJ, Zarzycka B, Lim HD, Kellam B, Mistry SN, Katrich V, Scammells PJ, Lane JR, Capuano B.
Fyfe TJ, et al.
J Med Chem. 2019 Jan 10;62(1):174-206. doi: 10.1021/acs.jmedchem.7b01565. Epub 2018 May 15.
J Med Chem. 2019.
PMID: 29683325
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Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D2 receptor.
Fyfe TJ, Kellam B, Mistry SN, Scammells PJ, Lane JR, Capuano B.
Fyfe TJ, et al.
Eur J Med Chem. 2019 Apr 15;168:474-490. doi: 10.1016/j.ejmech.2019.01.061. Epub 2019 Feb 11.
Eur J Med Chem. 2019.
PMID: 30849613
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Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor.
Fyfe TJ, Scammells PJ, Lane JR, Capuano B.
Fyfe TJ, et al.
Molecules. 2021 Jun 22;26(13):3799. doi: 10.3390/molecules26133799.
Molecules. 2021.
PMID: 34206465
Free PMC article.
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Examining the Role of the Linker in Bitopic N6-Substituted Adenosine Derivatives Acting as Biased Adenosine A1 Receptor Agonists.
Awalt JK, Nguyen ATN, Fyfe TJ, Thai BS, White PJ, Christopoulos A, Jörg M, May LT, Scammells PJ.
Awalt JK, et al. Among authors: fyfe tj.
J Med Chem. 2022 Jul 14;65(13):9076-9095. doi: 10.1021/acs.jmedchem.2c00320. Epub 2022 Jun 21.
J Med Chem. 2022.
PMID: 35729775
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Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites.
Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aubé J, Lane JR, Frankowski KJ, Sibley DR.
Luderman KD, et al. Among authors: fyfe tj.
Mol Pharmacol. 2018 Oct;94(4):1197-1209. doi: 10.1124/mol.118.113175. Epub 2018 Aug 1.
Mol Pharmacol. 2018.
PMID: 30068735
Free PMC article.
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