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Making the invisible enemy visible.
Croll TI, Diederichs K, Fischer F, Fyfe CD, Gao Y, Horrell S, Joseph AP, Kandler L, Kippes O, Kirsten F, Müller K, Nolte K, Payne AM, Reeves M, Richardson JS, Santoni G, Stäb S, Tronrud DE, von Soosten LC, Williams CJ, Thorn A. Croll TI, et al. Among authors: fyfe cd. Nat Struct Mol Biol. 2021 May;28(5):404-408. doi: 10.1038/s41594-021-00593-7. Nat Struct Mol Biol. 2021. PMID: 33972785 Free PMC article.
Making the invisible enemy visible.
Croll T, Diederichs K, Fischer F, Fyfe C, Gao Y, Horrell S, Joseph AP, Kandler L, Kippes O, Kirsten F, Müller K, Nolte K, Payne A, Reeves MG, Richardson J, Santoni G, Stäb S, Tronrud D, von Soosten L, Williams C, Thorn A. Croll T, et al. bioRxiv [Preprint]. 2020 Dec 28:2020.10.07.307546. doi: 10.1101/2020.10.07.307546. bioRxiv. 2020. PMID: 33052340 Free PMC article. Updated. Preprint.
Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme.
Kubiak X, Polsinelli I, Chavas LMG, Fyfe CD, Guillot A, Fradale L, Brewee C, Grimaldi S, Gerbaud G, Thureau A, Legrand P, Berteau O, Benjdia A. Kubiak X, et al. Among authors: fyfe cd. Nat Chem Biol. 2024 Mar;20(3):382-391. doi: 10.1038/s41589-023-01493-1. Epub 2023 Dec 29. Nat Chem Biol. 2024. PMID: 38158457
A Soluble Metabolon Synthesizes the Isoprenoid Lipid Ubiquinone.
Hajj Chehade M, Pelosi L, Fyfe CD, Loiseau L, Rascalou B, Brugière S, Kazemzadeh K, Vo CD, Ciccone L, Aussel L, Couté Y, Fontecave M, Barras F, Lombard M, Pierrel F. Hajj Chehade M, et al. Among authors: fyfe cd. Cell Chem Biol. 2019 Apr 18;26(4):482-492.e7. doi: 10.1016/j.chembiol.2018.12.001. Epub 2019 Jan 24. Cell Chem Biol. 2019. PMID: 30686758 Free article.
The UbiK protein is an accessory factor necessary for bacterial ubiquinone (UQ) biosynthesis and forms a complex with the UQ biogenesis factor UbiJ.
Loiseau L, Fyfe C, Aussel L, Hajj Chehade M, Hernández SB, Faivre B, Hamdane D, Mellot-Draznieks C, Rascalou B, Pelosi L, Velours C, Cornu D, Lombard M, Casadesús J, Pierrel F, Fontecave M, Barras F. Loiseau L, et al. J Biol Chem. 2017 Jul 14;292(28):11937-11950. doi: 10.1074/jbc.M117.789164. Epub 2017 May 30. J Biol Chem. 2017. PMID: 28559279 Free PMC article.
Structure of protease-cleaved Escherichia coli α-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment.
Fyfe CD, Grinter R, Josts I, Mosbahi K, Roszak AW, Cogdell RJ, Wall DM, Burchmore RJ, Byron O, Walker D. Fyfe CD, et al. Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1478-86. doi: 10.1107/S1399004715008548. Epub 2015 Jun 30. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26143919 Free PMC article.