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Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ. Rode B, et al. Among authors: futers ts. Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3. Nat Commun. 2017. PMID: 28839146 Free PMC article.
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
Imrie H, Viswambharan H, Sukumar P, Abbas A, Cubbon RM, Yuldasheva N, Gage M, Smith J, Galloway S, Skromna A, Rashid ST, Futers TS, Xuan S, Gatenby VK, Grant PJ, Channon KM, Beech DJ, Wheatcroft SB, Kearney MT. Imrie H, et al. Among authors: futers ts. Diabetes. 2012 Sep;61(9):2359-68. doi: 10.2337/db11-1494. Epub 2012 Jun 25. Diabetes. 2012. PMID: 22733797 Free PMC article.
Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels.
Shi J, Hyman AJ, De Vecchis D, Chong J, Lichtenstein L, Futers TS, Rouahi M, Salvayre AN, Auge N, Kalli AC, Beech DJ. Shi J, et al. Among authors: futers ts. Cell Rep. 2020 Oct 6;33(1):108225. doi: 10.1016/j.celrep.2020.108225. Cell Rep. 2020. PMID: 33027663 Free PMC article.
Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity.
Bartoli F, Debant M, Chuntharpursat-Bon E, Evans EL, Musialowski KE, Parsonage G, Morley LC, Futers TS, Sukumar P, Bowen TS, Kearney MT, Lichtenstein L, Roberts LD, Beech DJ. Bartoli F, et al. Among authors: futers ts. J Clin Invest. 2022 Mar 1;132(5):e141775. doi: 10.1172/JCI141775. J Clin Invest. 2022. PMID: 35025768 Free PMC article.
Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.
Parsonage G, Cuthbertson K, Endesh N, Murciano N, Hyman AJ, Revill CH, Povstyan OV, Chuntharpursat-Bon E, Debant M, Ludlow MJ, Futers TS, Lichtenstein L, Kinsella JA, Bartoli F, Rotordam MG, Becker N, Brüggemann A, Foster R, Beech DJ. Parsonage G, et al. Among authors: futers ts. Br J Pharmacol. 2023 Aug;180(16):2039-2063. doi: 10.1111/bph.15996. Epub 2023 Jan 31. Br J Pharmacol. 2023. PMID: 36457143 Free PMC article.
Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.
Endesh N, Chuntharpursat-Bon E, Revill C, Yuldasheva NY, Futers TS, Parsonage G, Humphreys N, Adamson A, Morley LC, Cubbon RM, Prasad KR, Foster R, Lichtenstein L, Beech DJ. Endesh N, et al. Among authors: futers ts. Liver Int. 2023 Sep;43(9):2026-2038. doi: 10.1111/liv.15646. Epub 2023 Jun 22. Liver Int. 2023. PMID: 37349903 Free PMC article.
31 results