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A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease.
Haage V, Tuddenham JF, Comandante-Lou N, Bautista A, Monzel A, Chiu R, Fujita M, Garcia FG, Bhattarai P, Patel R, Buonfiglioli A, Idiarte J, Herman M, Rinderspacher A, Mela A, Zhao W, Argenziano MG, Furnari JL, Banu MA, Landry DW, Bruce JN, Canoll P, Zhang Y, Nuriel T, Kizil C, Sproul AA, de Witte LD, Sims PA, Menon V, Picard M, De Jager PL. Haage V, et al. Among authors: furnari jl. bioRxiv [Preprint]. 2024 Feb 6:2024.02.06.579103. doi: 10.1101/2024.02.06.579103. bioRxiv. 2024. PMID: 38370689 Free PMC article. Preprint.
Scalable co-sequencing of RNA and DNA from individual nuclei.
Olsen TR, Talla P, Furnari J, Bruce JN, Canoll P, Zha S, Sims PA. Olsen TR, et al. bioRxiv [Preprint]. 2023 Feb 10:2023.02.09.527940. doi: 10.1101/2023.02.09.527940. bioRxiv. 2023. PMID: 36798358 Free PMC article. Preprint.
A cell state specific metabolic vulnerability to GPX4-dependent ferroptosis in glioblastoma.
Banu MA, Dovas A, Argenziano MG, Zhao W, Grajal HC, Higgins DMO, Sperring CP, Pereira B, Ye LF, Mahajan A, Humala N, Furnari JL, Upadhyayula PS, Zandkarimi F, Nguyen TTT, Wu PB, Hai L, Karan C, Razavilar A, Siegelin MD, Kitajewski J, Bruce JN, Stockwell BR, Sims PA, Canoll PD. Banu MA, et al. Among authors: furnari jl. bioRxiv [Preprint]. 2023 Feb 23:2023.02.22.529581. doi: 10.1101/2023.02.22.529581. bioRxiv. 2023. PMID: 36865302 Free PMC article. Preprint.
Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic and targetable tissue states.
Al-Dalahmah O, Argenziano MG, Kannan A, Mahajan A, Furnari J, Paryani F, Boyett D, Save A, Humala N, Khan F, Li J, Lu H, Sun Y, Tuddenham JF, Goldberg AR, Dovas A, Banu MA, Sudhakar T, Bush E, Lassman AB, McKhann GM, Gill BJA, Youngerman B, Sisti MB, Bruce JN, Sims PA, Menon V, Canoll P. Al-Dalahmah O, et al. Nat Commun. 2023 May 4;14(1):2586. doi: 10.1038/s41467-023-38186-1. Nat Commun. 2023. PMID: 37142563 Free PMC article.
Thoracic low grade glial neoplasm with concurrent H3 K27M and PTPN11 mutations.
Argenziano MG, Furnari JL, Miller ML, Sun Y, Banu MA, Neira JA, Snuderl M, Bruce JN, Welch M, McCormick P, Canoll P. Argenziano MG, et al. Among authors: furnari jl. Acta Neuropathol Commun. 2022 Apr 28;10(1):64. doi: 10.1186/s40478-022-01340-9. Acta Neuropathol Commun. 2022. PMID: 35484611 Free PMC article.
Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.
Spinazzi EF, Argenziano MG, Upadhyayula PS, Banu MA, Neira JA, Higgins DMO, Wu PB, Pereira B, Mahajan A, Humala N, Al-Dalahmah O, Zhao W, Save AV, Gill BJA, Boyett DM, Marie T, Furnari JL, Sudhakar TD, Stopka SA, Regan MS, Catania V, Good L, Zacharoulis S, Behl M, Petridis P, Jambawalikar S, Mintz A, Lignelli A, Agar NYR, Sims PA, Welch MR, Lassman AB, Iwamoto FM, D'Amico RS, Grinband J, Canoll P, Bruce JN. Spinazzi EF, et al. Among authors: furnari jl. Lancet Oncol. 2022 Nov;23(11):1409-1418. doi: 10.1016/S1470-2045(22)00599-X. Epub 2022 Oct 13. Lancet Oncol. 2022. PMID: 36243020 Free PMC article. Clinical Trial.