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The peripheral pro-nociceptive state induced by repetitive inflammatory stimuli involves continuous activation of protein kinase A and protein kinase C epsilon and its Na(V)1.8 sodium channel functional regulation in the primary sensory neuron.
Villarreal CF, Sachs D, Funez MI, Parada CA, de Queiroz Cunha F, Ferreira SH. Villarreal CF, et al. Among authors: funez mi. Biochem Pharmacol. 2009 Mar 1;77(5):867-77. doi: 10.1016/j.bcp.2008.11.015. Epub 2008 Nov 25. Biochem Pharmacol. 2009. PMID: 19073148
Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.
Funez MI, Ferrari LF, Duarte DB, Sachs D, Cunha FQ, Lorenzetti BB, Parada CA, Ferreira SH. Funez MI, et al. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19038-43. doi: 10.1073/pnas.0807922105. Epub 2008 Sep 17. Proc Natl Acad Sci U S A. 2008. PMID: 18799742 Free PMC article.
Morphine peripheral analgesia depends on activation of the PI3Kgamma/AKT/nNOS/NO/KATP signaling pathway.
Cunha TM, Roman-Campos D, Lotufo CM, Duarte HL, Souza GR, Verri WA Jr, Funez MI, Dias QM, Schivo IR, Domingues AC, Sachs D, Chiavegatto S, Teixeira MM, Hothersall JS, Cruz JS, Cunha FQ, Ferreira SH. Cunha TM, et al. Among authors: funez mi. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4442-7. doi: 10.1073/pnas.0914733107. Epub 2010 Feb 10. Proc Natl Acad Sci U S A. 2010. PMID: 20147620 Free PMC article.
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