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In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals.
Kamiya Y, Handa K, Miura T, Yanagi M, Shigeta K, Hina S, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: funatsu k. Chem Res Toxicol. 2021 Feb 15;34(2):507-513. doi: 10.1021/acs.chemrestox.0c00336. Epub 2021 Jan 12. Chem Res Toxicol. 2021. PMID: 33433197
Plasma and Hepatic Concentrations of Chemicals after Virtual Oral Administrations Extrapolated Using Rat Plasma Data and Simple Physiologically Based Pharmacokinetic Models.
Kamiya Y, Otsuka S, Miura T, Takaku H, Yamada R, Nakazato M, Nakamura H, Mizuno S, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: funatsu k. Chem Res Toxicol. 2019 Jan 22;32(1):211-218. doi: 10.1021/acs.chemrestox.8b00307. Epub 2018 Dec 18. Chem Res Toxicol. 2019. PMID: 30511563
Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats.
Kamiya Y, Otsuka S, Miura T, Yoshizawa M, Nakano A, Iwasaki M, Kobayashi Y, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: funatsu k. Chem Res Toxicol. 2020 Jul 20;33(7):1736-1751. doi: 10.1021/acs.chemrestox.0c00009. Epub 2020 Jun 19. Chem Res Toxicol. 2020. PMID: 32500706
An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats.
Kamiya Y, Handa K, Miura T, Ohori J, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: funatsu k. Chem Res Toxicol. 2021 Oct 18;34(10):2180-2183. doi: 10.1021/acs.chemrestox.1c00249. Epub 2021 Sep 29. Chem Res Toxicol. 2021. PMID: 34586804
Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.
Kamiya Y, Takaku H, Yamada R, Akase C, Abe Y, Sekiguchi Y, Murayama N, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: funatsu k. Toxicol Rep. 2020 Jan 14;7:149-154. doi: 10.1016/j.toxrep.2020.01.004. eCollection 2020. Toxicol Rep. 2020. PMID: 31993333 Free PMC article.
Prediction of permeability across intestinal cell monolayers for 219 disparate chemicals using in vitro experimental coefficients in a pH gradient system and in silico analyses by trivariate linear regressions and machine learning.
Kamiya Y, Omura A, Hayasaka R, Saito R, Sano I, Handa K, Ohori J, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: funatsu k. Biochem Pharmacol. 2021 Oct;192:114749. doi: 10.1016/j.bcp.2021.114749. Epub 2021 Aug 27. Biochem Pharmacol. 2021. PMID: 34461115
Correction to "Plasma and Hepatic Concentrations of Chemicals after Virtual Oral Administrations Extrapolated Using Rat Plasma Data and Simple Physiologically Based Pharmacokinetic Models".
Kamiya Y, Otsuka S, Miura T, Takaku H, Yamada R, Nakazato M, Nakamura H, Mizuno S, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: funatsu k. Chem Res Toxicol. 2019 Apr 15;32(4):792. doi: 10.1021/acs.chemrestox.9b00063. Epub 2019 Mar 22. Chem Res Toxicol. 2019. PMID: 30900873 No abstract available.
Correction to "An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats".
Kamiya Y, Handa K, Miura T, Ohori J, Shimizu M, Kitajima M, Shono F, Funatsu K, Yamazaki H. Kamiya Y, et al. Among authors: funatsu k. Chem Res Toxicol. 2022 Aug 15;35(8):1433. doi: 10.1021/acs.chemrestox.2c00225. Epub 2022 Jul 29. Chem Res Toxicol. 2022. PMID: 35905009 No abstract available.
185 results