Funamoto S - Search Results

1

Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase.

Moniruzzaman M, Ishihara S, Nobuhara M, Higashide H, Funamoto S. Moniruzzaman M, et al. Among authors: funamoto s. Biochem Biophys Res Commun. 2018 Jul 7;502(1):98-103. doi: 10.1016/j.bbrc.2018.05.126. Epub 2018 May 25. Biochem Biophys Res Commun. 2018. PMID: 29787759

2

Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states.

Osawa S, Funamoto S, Nobuhara M, Wada-Kakuda S, Shimojo M, Yagishita S, Ihara Y. Osawa S, et al. Among authors: funamoto s. J Biol Chem. 2008 Jul 11;283(28):19283-92. doi: 10.1074/jbc.M705954200. Epub 2008 May 14. J Biol Chem. 2008. PMID: 18480063 Free article.

3

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y. Takami M, et al. Among authors: funamoto s. J Neurosci. 2009 Oct 14;29(41):13042-52. doi: 10.1523/JNEUROSCI.2362-09.2009. J Neurosci. 2009. PMID: 19828817 Free PMC article.

4

Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3.

Kang MS, Baek SH, Chun YS, Moore AZ, Landman N, Berman D, Yang HO, Morishima-Kawashima M, Osawa S, Funamoto S, Ihara Y, Di Paolo G, Park JH, Chung S, Kim TW. Kang MS, et al. Among authors: funamoto s. J Biol Chem. 2013 Jul 19;288(29):20868-20882. doi: 10.1074/jbc.M112.445734. Epub 2013 May 30. J Biol Chem. 2013. PMID: 23723072 Free PMC article.

5

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.

Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y. Funamoto S, et al. Nat Commun. 2013;4:2529. doi: 10.1038/ncomms3529. Nat Commun. 2013. PMID: 24108142 Free PMC article.

6

The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.

Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S. Kokawa A, et al. Among authors: funamoto s. Acta Neuropathol Commun. 2015 Nov 4;3:66. doi: 10.1186/s40478-015-0247-6. Acta Neuropathol Commun. 2015. PMID: 26531305 Free PMC article.

7

Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.

Higashide H, Ishihara S, Nobuhara M, Ihara Y, Funamoto S. Higashide H, et al. Among authors: funamoto s. J Neurochem. 2017 Mar;140(6):955-962. doi: 10.1111/jnc.13942. Epub 2017 Jan 30. J Neurochem. 2017. PMID: 28032911 Free article.

8

Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.

Urano Y, Takahachi M, Higashiura R, Fujiwara H, Funamoto S, Imai S, Futai E, Okuda M, Sugimoto H, Noguchi N. Urano Y, et al. Among authors: funamoto s. Cells. 2020 Feb 3;9(2):349. doi: 10.3390/cells9020349. Cells. 2020. PMID: 32028683 Free PMC article.

9

γ-Secretase Activity Is Associated with Braak Senile Plaque Stages.

Kakuda N, Yamaguchi H, Akazawa K, Hata S, Suzuki T, Hatsuta H, Murayama S, Funamoto S, Ihara Y. Kakuda N, et al. Among authors: funamoto s. Am J Pathol. 2020 Jun;190(6):1323-1331. doi: 10.1016/j.ajpath.2020.02.009. Epub 2020 Mar 20. Am J Pathol. 2020. PMID: 32201261 Free article.

10

Successive cleavage of β-amyloid precursor protein by γ-secretase.

Funamoto S, Tagami S, Okochi M, Morishima-Kawashima M. Funamoto S, et al. Semin Cell Dev Biol. 2020 Sep;105:64-74. doi: 10.1016/j.semcdb.2020.04.002. Epub 2020 Apr 27. Semin Cell Dev Biol. 2020. PMID: 32354467 Review.

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