Fulton MG - Search Results

1

Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063.

Kharade SV, Sanchez-Andres JV, Fulton MG, Shelton EL, Blobaum AL, Engers DW, Hofmann CS, Dadi PK, Lantier L, Jacobson DA, Lindsley CW, Denton JS. Kharade SV, et al. Among authors: fulton mg. J Pharmacol Exp Ther. 2019 Sep;370(3):350-359. doi: 10.1124/jpet.119.257204. Epub 2019 Jun 14. J Pharmacol Exp Ther. 2019. PMID: 31201216 Free PMC article.

2

Discovery and optimization of a novel CNS penetrant series of mGlu₄ PAMs based on a 1,4-thiazepane core with in vivo efficacy in a preclinical Parkinsonian model.

Kent CN, Fulton MG, Stillwell KJ, Dickerson JW, Loch MT, Rodriguez AL, Blobaum AL, Boutaud O, Rook JL, Niswender CM, Conn PJ, Lindsley CW. Kent CN, et al. Among authors: fulton mg. Bioorg Med Chem Lett. 2021 Apr 1;37:127838. doi: 10.1016/j.bmcl.2021.127838. Epub 2021 Feb 5. Bioorg Med Chem Lett. 2021. PMID: 33556572

3

Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu_2/4 heterodimeric receptor results in a compound with mGlu_2/2 homodimer selectivity.

Fulton MG, Loch MT, Rodriguez AL, Lin X, Javitch JA, Conn PJ, Niswender CM, Lindsley CW. Fulton MG, et al. Bioorg Med Chem Lett. 2020 Jul 1;30(13):127212. doi: 10.1016/j.bmcl.2020.127212. Epub 2020 Apr 25. Bioorg Med Chem Lett. 2020. PMID: 32371100 Free PMC article.

4

Challenges in the Discovery and Optimization of mGlu_2/4 Heterodimer Positive Allosteric Modulators.

Fulton MG, Loch MT, Cuoco CA, Rodriguez AL, Days E, Vinson PN, Kozek KA, Weaver CD, Blobaum AL, Conn PJ, Niswender CM, Lindsley CW. Fulton MG, et al. Lett Drug Des Discov. 2019 Dec;16(12):1387-1394. doi: 10.2174/1570180815666181017131349. Lett Drug Des Discov. 2019. PMID: 32201485 Free PMC article.

5

Formal Total Synthesis of Pericoannosin A.

Fulton MG, Bertron JL, Reed CW, Lindsley CW. Fulton MG, et al. J Org Chem. 2019 Sep 20;84(18):12187-12191. doi: 10.1021/acs.joc.9b01846. Epub 2019 Sep 4. J Org Chem. 2019. PMID: 31436090

6

Structure of a reaction intermediate mimic in t6A biosynthesis bound in the active site of the TsaBD heterodimer from Escherichia coli.

Kopina BJ, Missoury S, Collinet B, Fulton MG, Cirio C, van Tilbeurgh H, Lauhon CT. Kopina BJ, et al. Among authors: fulton mg. Nucleic Acids Res. 2021 Feb 26;49(4):2141-2160. doi: 10.1093/nar/gkab026. Nucleic Acids Res. 2021. PMID: 33524148 Free PMC article.

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