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Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia.
Cancer Res Commun. 2023 Feb 21;3(2):297-308. doi: 10.1158/2767-9764.CRC-22-0259. eCollection 2023 Feb.
Cancer Res Commun. 2023.
PMID: 36860654
Free PMC article.
Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-2100.
Watanabe T, Yamashita S, Ureshino H, Kamachi K, Kurahashi Y, Fukuda-Kurahashi Y, Yoshida N, Hattori N, Nakamura H, Sato A, Kawaguchi A, Sueoka-Aragane N, Kojima K, Okada S, Ushijima T, Kimura S, Sueoka E.
Watanabe T, et al. Among authors: fukuda kurahashi y.
Blood. 2020 Aug 13;136(7):871-884. doi: 10.1182/blood.2019003084.
Blood. 2020.
PMID: 32391874
Free article.
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Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects.
Ureshino H, Kurahashi Y, Watanabe T, Yamashita S, Kamachi K, Yamamoto Y, Fukuda-Kurahashi Y, Yoshida-Sakai N, Hattori N, Hayashi Y, Kawaguchi A, Tohyama K, Okada S, Harada H, Ushijima T, Kimura S.
Ureshino H, et al. Among authors: fukuda kurahashi y.
Mol Cancer Ther. 2021 Aug;20(8):1412-1421. doi: 10.1158/1535-7163.MCT-20-1125. Epub 2021 May 27.
Mol Cancer Ther. 2021.
PMID: 34045225
Free PMC article.
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Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia.
Kamachi K, Ureshino H, Watanabe T, Yoshida N, Yamamoto Y, Kurahashi Y, Fukuda-Kurahashi Y, Hayashi Y, Hirai H, Yamashita S, Ushijima T, Okada S, Kimura S.
Kamachi K, et al. Among authors: fukuda kurahashi y.
Cancer Lett. 2022 Feb 1;526:273-283. doi: 10.1016/j.canlet.2021.11.032. Epub 2021 Dec 4.
Cancer Lett. 2022.
PMID: 34875342
Free article.
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Adult T-cell leukemia-lymphoma acquires resistance to DNA demethylating agents through dysregulation of enzymes involved in pyrimidine metabolism.
Yoshida-Sakai N, Watanabe T, Yamamoto Y, Ureshino H, Kamachi K, Kurahashi Y, Fukuda-Kurahashi Y, Kimura S.
Yoshida-Sakai N, et al. Among authors: fukuda kurahashi y.
Int J Cancer. 2022 Apr 1;150(7):1184-1197. doi: 10.1002/ijc.33901. Epub 2021 Dec 29.
Int J Cancer. 2022.
PMID: 34913485
Free PMC article.
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Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL.
Kurahashi Y, Watanabe T, Yamamoto Y, Ureshino H, Kamachi K, Yoshida-Sakai N, Fukuda-Kurahashi Y, Yamashita S, Hattori N, Nakamura H, Kawaguchi A, Ushijima T, Sueoka E, Kimura S.
Kurahashi Y, et al. Among authors: fukuda kurahashi y.
Blood Adv. 2023 Apr 25;7(8):1545-1559. doi: 10.1182/bloodadvances.2022008362.
Blood Adv. 2023.
PMID: 36516085
Free PMC article.
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A Combination of Alectinib and DNA-Demethylating Agents Synergistically Inhibits Anaplastic-Lymphoma-Kinase-Positive Anaplastic Large-Cell Lymphoma Cell Proliferation.
Kawasoe K, Watanabe T, Yoshida-Sakai N, Yamamoto Y, Kurahashi Y, Kidoguchi K, Ureshino H, Kamachi K, Fukuda-Kurahashi Y, Kimura S.
Kawasoe K, et al. Among authors: fukuda kurahashi y.
Cancers (Basel). 2023 Oct 21;15(20):5089. doi: 10.3390/cancers15205089.
Cancers (Basel). 2023.
PMID: 37894456
Free PMC article.
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Reprogramming of pyrimidine nucleotide metabolism supports vigorous cell proliferation of normal and malignant T cells.
Watanabe T, Yamamoto Y, Kurahashi Y, Kawasoe K, Kidoguchi K, Ureshino H, Kamachi K, Yoshida-Sakai N, Fukuda-Kurahashi Y, Nakamura H, Okada S, Sueoka E, Kimura S.
Watanabe T, et al. Among authors: fukuda kurahashi y.
Blood Adv. 2024 Mar 26;8(6):1345-1358. doi: 10.1182/bloodadvances.2023011131.
Blood Adv. 2024.
PMID: 38190613
Free PMC article.
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