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The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia.
Kozawa K, Sekai M, Ohba K, Ito S, Sako H, Maruyama T, Kakeno M, Shirai T, Kuromiya K, Kamasaki T, Kohashi K, Tanaka S, Ishikawa S, Sato N, Asano S, Suzuki H, Tanimura N, Mukai Y, Gotoh N, Tanino M, Tanaka S, Natsuga K, Soga T, Nakamura T, Yabuta Y, Saitou M, Ito T, Matsuura K, Tsunoda M, Kikumori T, Iida T, Mizutani Y, Miyai Y, Kaibuchi K, Enomoto A, Fujita Y. Kozawa K, et al. Among authors: fujita y. Curr Biol. 2021 Jul 26;31(14):3086-3097.e7. doi: 10.1016/j.cub.2021.04.078. Epub 2021 Jun 3. Curr Biol. 2021. PMID: 34087104 Free article.
Filamin acts as a key regulator in epithelial defence against transformed cells.
Kajita M, Sugimura K, Ohoka A, Burden J, Suganuma H, Ikegawa M, Shimada T, Kitamura T, Shindoh M, Ishikawa S, Yamamoto S, Saitoh S, Yako Y, Takahashi R, Okajima T, Kikuta J, Maijima Y, Ishii M, Tada M, Fujita Y. Kajita M, et al. Among authors: fujita y. Nat Commun. 2014 Jul 31;5:4428. doi: 10.1038/ncomms5428. Nat Commun. 2014. PMID: 25079702 Free article.
EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.
Ohoka A, Kajita M, Ikenouchi J, Yako Y, Kitamoto S, Kon S, Ikegawa M, Shimada T, Ishikawa S, Fujita Y. Ohoka A, et al. Among authors: fujita y. J Cell Sci. 2015 Feb 15;128(4):781-9. doi: 10.1242/jcs.163113. Epub 2015 Jan 20. J Cell Sci. 2015. PMID: 25609711
Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells.
Saitoh S, Maruyama T, Yako Y, Kajita M, Fujioka Y, Ohba Y, Kasai N, Sugama N, Kon S, Ishikawa S, Hayashi T, Yamazaki T, Tada M, Fujita Y. Saitoh S, et al. Among authors: fujita y. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2327-E2336. doi: 10.1073/pnas.1602349114. Epub 2017 Mar 7. Proc Natl Acad Sci U S A. 2017. PMID: 28270608 Free PMC article.
4,389 results