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Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice.
Watanabe Y, Fujisaka S, Morinaga Y, Watanabe S, Nawaz A, Hatta H, Kado T, Nishimura A, Bilal M, Aslam MR, Honda K, Nakagawa Y, Softic S, Hirabayashi K, Nakagawa T, Nagai Y, Tobe K. Watanabe Y, et al. Among authors: fujisaka s. Mol Metab. 2023 Nov;77:101797. doi: 10.1016/j.molmet.2023.101797. Epub 2023 Sep 12. Mol Metab. 2023. PMID: 37709134 Free PMC article.
Negative correlation between organ heteroplasmy, particularly hepatic heteroplasmy, and age at death revealed by post-mortem studies of m.3243A > G cases.
Yagi K, Okazaki S, Ohbatake A, Nakaya M, Liu J, Arite E, Miyamoto Y, Ito N, Nakano K, Yamaaki N, Honoki H, Fujisaka S, Chujo D, Tsunoda SI, Yanagimoto K, Nozue T, Yamada M, Ooe K, Araki T, Nakashima A, Azami Y, Sodemoto Y, Tadokoro K, Nagano M, Noguchi T, Nohara A, Origasa H, Niida Y, Tada H. Yagi K, et al. Among authors: fujisaka s. Mol Genet Metab. 2023 Nov;140(3):107691. doi: 10.1016/j.ymgme.2023.107691. Epub 2023 Aug 28. Mol Genet Metab. 2023. PMID: 37660570 Free article.
Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. Among authors: fujisaka s. Metabolism. 2023 Aug;145:155591. doi: 10.1016/j.metabol.2023.155591. Epub 2023 May 23. Metabolism. 2023. PMID: 37230214
Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice.
Kasai K, Igarashi N, Tada Y, Kani K, Takano S, Yanagibashi T, Usui-Kawanishi F, Fujisaka S, Watanabe S, Ichimura-Shimizu M, Takatsu K, Tobe K, Tsuneyama K, Furusawa Y, Nagai Y. Kasai K, et al. Among authors: fujisaka s. Int J Mol Sci. 2023 Feb 17;24(4):4050. doi: 10.3390/ijms24044050. Int J Mol Sci. 2023. PMID: 36835461 Free PMC article.
Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.
Park SH, Helsley RN, Fadhul T, Willoughby JLS, Noetzli L, Tu HC, Solheim MH, Fujisaka S, Pan H, Dreyfuss JM, Bons J, Rose J, King CD, Schilling B, Lusis AJ, Pan C, Gupta M, Kulkarni RN, Fitzgerald K, Kern PA, Divanovic S, Kahn CR, Softic S. Park SH, et al. Among authors: fujisaka s. bioRxiv [Preprint]. 2023 Jan 27:2023.01.27.525605. doi: 10.1101/2023.01.27.525605. bioRxiv. 2023. PMID: 36747758 Free PMC article. Updated. Preprint.
The gut microbiome: a core regulator of metabolism.
Fujisaka S, Watanabe Y, Tobe K. Fujisaka S, et al. J Endocrinol. 2023 Jan 19;256(3):e220111. doi: 10.1530/JOE-22-0111. Print 2023 Mar 1. J Endocrinol. 2023. PMID: 36458804 Free PMC article. Review.
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration.
Nawaz A, Bilal M, Fujisaka S, Kado T, Aslam MR, Ahmed S, Okabe K, Igarashi Y, Watanabe Y, Kuwano T, Tsuneyama K, Nishimura A, Nishida Y, Yamamoto S, Sasahara M, Imura J, Mori H, Matzuk MM, Kudo F, Manabe I, Uezumi A, Nakagawa T, Oishi Y, Tobe K. Nawaz A, et al. Among authors: fujisaka s. Nat Commun. 2022 Nov 21;13(1):7058. doi: 10.1038/s41467-022-34191-y. Nat Commun. 2022. PMID: 36411280 Free PMC article.
72 results