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Driving external chemistry optimization via operations management principles.
Drug Discov Today. 2014 Mar;19(3):289-94. doi: 10.1016/j.drudis.2013.07.017. Epub 2013 Aug 21.
Drug Discov Today. 2014.
PMID: 23973340
Review.
Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors.
Arcari JT, Beebe JS, Berliner MA, Bernardo V, Boehm M, Borzillo GV, Clark T, Cohen BD, Connell RD, Frost HN, Gordon DA, Hungerford WM, Kakar SM, Kanter A, Keene NF, Knauth EA, Lagreca SD, Lu Y, Martinez-Alsina L, Marx MA, Morris J, Patel NC, Savage D, Soderstrom CI, Thompson C, Tkalcevic G, Tom NJ, Vajdos FF, Valentine JJ, Vincent PW, Wessel MD, Chen JM.
Arcari JT, et al. Among authors: frost hn.
Bioorg Med Chem Lett. 2013 May 15;23(10):3059-63. doi: 10.1016/j.bmcl.2013.03.012. Epub 2013 Mar 21.
Bioorg Med Chem Lett. 2013.
PMID: 23566514
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Enantioselective synthesis of nicotinic receptor probe 7,8-difluoro-1,2,3,4,5,6- hexahydro-1,5-methano-3-benzazocine.
Bashore CG, Vetelino MG, Wirtz MC, Brooks PR, Frost HN, McDermott RE, Whritenour DC, Ragan JA, Rutherford JL, Makowski TW, Brenek SJ, Coe JW.
Bashore CG, et al. Among authors: frost hn.
Org Lett. 2006 Dec 21;8(26):5947-50. doi: 10.1021/ol0623062.
Org Lett. 2006.
PMID: 17165901
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Activation of allylic C-F bonds: palladium-catalyzed allylic amination of 3,3-difluoropropenes.
Pigeon X, Bergeron M, Barabé F, Dubé P, Frost HN, Paquin JF.
Pigeon X, et al. Among authors: frost hn.
Angew Chem Int Ed Engl. 2010 Feb 1;49(6):1123-7. doi: 10.1002/anie.200904747.
Angew Chem Int Ed Engl. 2010.
PMID: 20043303
No abstract available.
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