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In-depth mechanistic analysis including high-throughput RNA sequencing in the prediction of functional and structural cardiotoxicants using hiPSC cardiomyocytes.
Rosell-Hidalgo A, Bruhn C, Shardlow E, Barton R, Ryder S, Samatov T, Hackmann A, Aquino GR, Fernandes Dos Reis M, Galatenko V, Fritsch R, Dohrmann C, Walker PA. Rosell-Hidalgo A, et al. Among authors: fritsch r. Expert Opin Drug Metab Toxicol. 2023 Nov 23:1-23. doi: 10.1080/17425255.2023.2273378. Online ahead of print. Expert Opin Drug Metab Toxicol. 2023. PMID: 37995132
Impact of the PI3K-alpha inhibitor alpelisib on everolimus resistance and somatostatin receptor expression in an orthotopic pancreatic NEC xenograft mouse model.
Mohan AM, Prasad S, Schmitz-Peiffer F, Lange C, Lukas M, Koziolek EJ, Albrecht J, Messroghli D, Stein U, Ilmer M, Wang K, Schober L, Reul A, Maurer J, Friemel J, Weber A, Zuellig RA, Hantel C, Fritsch R, Reincke M, Pacak K, Grossman AB, Auernhammer CJ, Beuschlein F, Brenner W, Beindorff N, Nölting S. Mohan AM, et al. Among authors: fritsch r. Endocr Relat Cancer. 2023 Nov 30;31(1):e230041. doi: 10.1530/ERC-23-0041. Print 2024 Jan 1. Endocr Relat Cancer. 2023. PMID: 37943630
Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer (KEYNOTE-859): a multicentre, randomised, double-blind, phase 3 trial.
Rha SY, Oh DY, Yañez P, Bai Y, Ryu MH, Lee J, Rivera F, Alves GV, Garrido M, Shiu KK, Fernández MG, Li J, Lowery MA, Çil T, Cruz FM, Qin S, Luo S, Pan H, Wainberg ZA, Yin L, Bordia S, Bhagia P, Wyrwicz LS; KEYNOTE-859 investigators. Rha SY, et al. Lancet Oncol. 2023 Nov;24(11):1181-1195. doi: 10.1016/S1470-2045(23)00515-6. Epub 2023 Oct 21. Lancet Oncol. 2023. PMID: 37875143 Clinical Trial.
BRAFΔβ3-αC in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability.
Lauinger M, Christen D, Klar RFU, Roubaty C, Heilig CE, Stumpe M, Knox JJ, Radulovich N, Tamblyn L, Xie IY, Horak P, Forschner A, Bitzer M, Wittel UA, Boerries M, Ball CR, Heining C, Glimm H, Fröhlich M, Hübschmann D, Gallinger S, Fritsch R, Fröhling S, O'Kane GM, Dengjel J, Brummer T. Lauinger M, et al. Among authors: fritsch r. Sci Adv. 2023 Sep;9(35):eade7486. doi: 10.1126/sciadv.ade7486. Epub 2023 Sep 1. Sci Adv. 2023. PMID: 37656784 Free article.
Allium sulaimanicum: A new Allium species and section from Pakistan.
Khan N, Friesen N, Sultan A, Fritsch RM, Khan T, Ishaq K. Khan N, et al. Among authors: fritsch rm. Front Plant Sci. 2022 Dec 14;13:1020440. doi: 10.3389/fpls.2022.1020440. eCollection 2022. Front Plant Sci. 2022. PMID: 36589053 Free PMC article.
Retrospective Analysis of Treatment Pathways in Patients With BRAFV600E-mutant Metastatic Colorectal Carcinoma - MORSECRC.
Gerger A, Eisterer W, Fuxius S, Bastian S, Koeberle D, Welslau M, Sanoyan DA, Maas C, Uhlig J, Fenchel K, Greil R, VON DER Heyde E, Agocs GR, Weide R, Schwager M, Reichenbach F, Modest DP, Fritsch R. Gerger A, et al. Among authors: fritsch r. Anticancer Res. 2022 Oct;42(10):4773-4785. doi: 10.21873/anticanres.15982. Anticancer Res. 2022. PMID: 36191968 Free article.
254 results