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Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Bolik J, Krause F, Stevanovic M, Gandraß M, Thomsen I, Schacht SS, Rieser E, Müller M, Schumacher N, Fritsch J, Wichert R, Galun E, Bergmann J, Röder C, Schafmayer C, Egberts JH, Becker-Pauly C, Saftig P, Lucius R, Schneider-Brachert W, Barikbin R, Adam D, Voss M, Hitzl W, Krüger A, Strilic B, Sagi I, Walczak H, Rose-John S, Schmidt-Arras D. Bolik J, et al. Among authors: fritsch j. J Exp Med. 2022 Jan 3;219(1):e20201039. doi: 10.1084/jem.20201039. Epub 2021 Dec 17. J Exp Med. 2022. PMID: 34919140 Free PMC article.
Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells.
Haselmann V, Kurz A, Bertsch U, Hübner S, Olempska-Müller M, Fritsch J, Häsler R, Pickl A, Fritsche H, Annewanter F, Engler C, Fleig B, Bernt A, Röder C, Schmidt H, Gelhaus C, Hauser C, Egberts JH, Heneweer C, Rohde AM, Böger C, Knippschild U, Röcken C, Adam D, Walczak H, Schütze S, Janssen O, Wulczyn FG, Wajant H, Kalthoff H, Trauzold A. Haselmann V, et al. Among authors: fritsch j. Gastroenterology. 2014 Jan;146(1):278-90. doi: 10.1053/j.gastro.2013.10.009. Epub 2013 Oct 9. Gastroenterology. 2014. PMID: 24120475
Extracellular sphingomyelinase activity impairs TNF-α-induced endothelial cell death via ADAM17 activation and TNF receptor 1 shedding.
Sommer A, Düppe M, Baumecker L, Kordowski F, Büch J, Chico JF, Fritsch J, Schütze S, Adam D, Sperrhacke M, Bhakdi S, Reiss K. Sommer A, et al. Among authors: fritsch j. Oncotarget. 2017 Aug 7;8(42):72584-72596. doi: 10.18632/oncotarget.19983. eCollection 2017 Sep 22. Oncotarget. 2017. PMID: 29069811 Free PMC article.
Palmitoylation is required for TNF-R1 signaling.
Zingler P, Särchen V, Glatter T, Caning L, Saggau C, Kathayat RS, Dickinson BC, Adam D, Schneider-Brachert W, Schütze S, Fritsch J. Zingler P, et al. Among authors: fritsch j. Cell Commun Signal. 2019 Aug 5;17(1):90. doi: 10.1186/s12964-019-0405-8. Cell Commun Signal. 2019. PMID: 31382980 Free PMC article.
Selective HSP90β inhibition results in TNF and TRAIL mediated HIF1α degradation.
Heck AL, Mishra S, Prenzel T, Feulner L, Achhammer E, Särchen V, Blagg BSJ, Schneider-Brachert W, Schütze S, Fritsch J. Heck AL, et al. Among authors: fritsch j. Immunobiology. 2021 Mar;226(2):152070. doi: 10.1016/j.imbio.2021.152070. Epub 2021 Feb 5. Immunobiology. 2021. PMID: 33639524 Free article.
314 results