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Discovery of quinazoline HPK1 inhibitors with high cellular potency.
Toure M, Johnson T, Li B, Schmidt R, Ma H, Neagu C, Lopez AU, Wang Y, Guler S, Xiao Y, Henkes R, Ho K, Zhang S, Chu CL, Gundra UM, Porichis F, Li L, Maurer CK, Fang Z, Musil D, DiPoto M, Friis E, Jones R, Jones C, Cummings J, Chekler E, Tanzer EM, Huck B, Sherer B. Toure M, et al. Among authors: friis e. Bioorg Med Chem. 2023 Sep 7;92:117423. doi: 10.1016/j.bmc.2023.117423. Epub 2023 Jul 27. Bioorg Med Chem. 2023. PMID: 37531921
Module walking using an SH3-like cell-wall-binding domain leads to a new GH184 family of muramidases.
Moroz OV, Blagova E, Lebedev AA, Skov LK, Pache RA, Schnorr KM, Kiemer L, Friis EP, Nymand-Grarup S, Ming L, Ye L, Klausen M, Cohn MT, Schmidt EGW, Davies GJ, Wilson KS. Moroz OV, et al. Among authors: friis ep. Acta Crystallogr D Struct Biol. 2023 Aug 1;79(Pt 8):706-720. doi: 10.1107/S2059798323005004. Epub 2023 Jul 10. Acta Crystallogr D Struct Biol. 2023. PMID: 37428847 Free PMC article.
239 results