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Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data.
Lai X, Geier OM, Fleischer T, Garred Ø, Borgen E, Funke SW, Kumar S, Rognes ME, Seierstad T, Børresen-Dale AL, Kristensen VN, Engebraaten O, Köhn-Luque A, Frigessi A. Lai X, et al. Among authors: frigessi a. Cancer Res. 2019 Aug 15;79(16):4293-4304. doi: 10.1158/0008-5472.CAN-18-1804. Epub 2019 May 22. Cancer Res. 2019. PMID: 31118201 Clinical Trial.
Tilting the lasso by knowledge-based post-processing.
Tharmaratnam K, Sperrin M, Jaki T, Reppe S, Frigessi A. Tharmaratnam K, et al. Among authors: frigessi a. BMC Bioinformatics. 2016 Sep 2;17(1):344. doi: 10.1186/s12859-016-1210-7. BMC Bioinformatics. 2016. PMID: 27590269 Free PMC article.
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.
Menden MP, Wang D, Mason MJ, Szalai B, Bulusu KC, Guan Y, Yu T, Kang J, Jeon M, Wolfinger R, Nguyen T, Zaslavskiy M; AstraZeneca-Sanger Drug Combination DREAM Consortium; Jang IS, Ghazoui Z, Ahsen ME, Vogel R, Neto EC, Norman T, Tang EKY, Garnett MJ, Veroli GYD, Fawell S, Stolovitzky G, Guinney J, Dry JR, Saez-Rodriguez J. Menden MP, et al. Nat Commun. 2019 Jun 17;10(1):2674. doi: 10.1038/s41467-019-09799-2. Nat Commun. 2019. PMID: 31209238 Free PMC article.
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment.
Tekpli X, Lien T, Røssevold AH, Nebdal D, Borgen E, Ohnstad HO, Kyte JA, Vallon-Christersson J, Fongaard M, Due EU, Svartdal LG, Sveli MAT, Garred Ø; OSBREAC; Frigessi A, Sahlberg KK, Sørlie T, Russnes HG, Naume B, Kristensen VN. Tekpli X, et al. Among authors: frigessi a. Nat Commun. 2019 Dec 3;10(1):5499. doi: 10.1038/s41467-019-13329-5. Nat Commun. 2019. PMID: 31796750 Free PMC article.
DNA methylation at enhancers identifies distinct breast cancer lineages.
Fleischer T, Tekpli X, Mathelier A, Wang S, Nebdal D, Dhakal HP, Sahlberg KK, Schlichting E; Oslo Breast Cancer Research Consortium (OSBREAC); Børresen-Dale AL, Borgen E, Naume B, Eskeland R, Frigessi A, Tost J, Hurtado A, Kristensen VN. Fleischer T, et al. Among authors: frigessi a. Nat Commun. 2017 Nov 9;8(1):1379. doi: 10.1038/s41467-017-00510-x. Nat Commun. 2017. PMID: 29123100 Free PMC article.
Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort.
Tramm T, Mohammed H, Myhre S, Kyndi M, Alsner J, Børresen-Dale AL, Sørlie T, Frigessi A, Overgaard J. Tramm T, et al. Among authors: frigessi a. Clin Cancer Res. 2014 Oct 15;20(20):5272-80. doi: 10.1158/1078-0432.CCR-14-0458. Epub 2014 Aug 22. Clin Cancer Res. 2014. PMID: 25149560
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