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Cryo-EM structures of lipidic fibrils of amyloid-β (1-40).
Frieg B, Han M, Giller K, Dienemann C, Riedel D, Becker S, Andreas LB, Griesinger C, Schröder GF. Frieg B, et al. Nat Commun. 2024 Feb 13;15(1):1297. doi: 10.1038/s41467-023-43822-x. Nat Commun. 2024. PMID: 38351005 Free PMC article.
Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.
Bhatia S, Diedrich D, Frieg B, Ahlert H, Stein S, Bopp B, Lang F, Zang T, Kröger T, Ernst T, Kögler G, Krieg A, Lüdeke S, Kunkel H, Rodrigues Moita AJ, Kassack MU, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK, Hauer J. Bhatia S, et al. Among authors: frieg b. Blood. 2018 Jul 19;132(3):307-320. doi: 10.1182/blood-2017-10-810986. Epub 2018 May 3. Blood. 2018. PMID: 29724897 Free PMC article.
The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils.
Antonschmidt L, Matthes D, Dervişoğlu R, Frieg B, Dienemann C, Leonov A, Nimerovsky E, Sant V, Ryazanov S, Giese A, Schröder GF, Becker S, de Groot BL, Griesinger C, Andreas LB. Antonschmidt L, et al. Among authors: frieg b. Nat Commun. 2022 Sep 14;13(1):5385. doi: 10.1038/s41467-022-32797-w. Nat Commun. 2022. PMID: 36104315 Free PMC article.
Molecular interactions of FG nucleoporin repeats at high resolution.
Ibáñez de Opakua A, Geraets JA, Frieg B, Dienemann C, Savastano A, Rankovic M, Cima-Omori MS, Schröder GF, Zweckstetter M. Ibáñez de Opakua A, et al. Among authors: frieg b. Nat Chem. 2022 Nov;14(11):1278-1285. doi: 10.1038/s41557-022-01035-7. Epub 2022 Sep 22. Nat Chem. 2022. PMID: 36138110 Free PMC article.
The 3D structure of lipidic fibrils of α-synuclein.
Frieg B, Antonschmidt L, Dienemann C, Geraets JA, Najbauer EE, Matthes D, de Groot BL, Andreas LB, Becker S, Griesinger C, Schröder GF. Frieg B, et al. Nat Commun. 2022 Nov 10;13(1):6810. doi: 10.1038/s41467-022-34552-7. Nat Commun. 2022. PMID: 36357403 Free PMC article.
Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Zielinski M, Peralta Reyes FS, Gremer L, Schemmert S, Frieg B, Schäfer LU, Willuweit A, Donner L, Elvers M, Nilsson LNG, Syvänen S, Sehlin D, Ingelsson M, Willbold D, Schröder GF. Zielinski M, et al. Among authors: frieg b. Nat Neurosci. 2023 Dec;26(12):2073-2080. doi: 10.1038/s41593-023-01484-4. Epub 2023 Nov 16. Nat Neurosci. 2023. PMID: 37973869 Free PMC article.
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