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The toxic effect of R350P mutant desmin in striated muscle of man and mouse.
Clemen CS, Stöckigt F, Strucksberg KH, Chevessier F, Winter L, Schütz J, Bauer R, Thorweihe JM, Wenzel D, Schlötzer-Schrehardt U, Rasche V, Krsmanovic P, Katus HA, Rottbauer W, Just S, Müller OJ, Friedrich O, Meyer R, Herrmann H, Schrickel JW, Schröder R. Clemen CS, et al. Among authors: friedrich o. Acta Neuropathol. 2015 Feb;129(2):297-315. doi: 10.1007/s00401-014-1363-2. Epub 2014 Nov 14. Acta Neuropathol. 2015. PMID: 25394388 Free PMC article.
Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice.
Diermeier S, Iberl J, Vetter K, Haug M, Pollmann C, Reischl B, Buttgereit A, Schürmann S, Spörrer M, Goldmann WH, Fabry B, Elhamine F, Stehle R, Pfitzer G, Winter L, Clemen CS, Herrmann H, Schröder R, Friedrich O. Diermeier S, et al. Among authors: friedrich o. Sci Rep. 2017 May 3;7(1):1391. doi: 10.1038/s41598-017-01485-x. Sci Rep. 2017. PMID: 28469177 Free PMC article.
The MyoRobot technology discloses a premature biomechanical decay of skeletal muscle fiber bundles derived from R349P desminopathy mice.
Haug M, Meyer C, Reischl B, Prölß G, Vetter K, Iberl J, Nübler S, Schürmann S, Rupitsch SJ, Heckel M, Pöschel T, Winter L, Herrmann H, Clemen CS, Schröder R, Friedrich O. Haug M, et al. Among authors: friedrich o. Sci Rep. 2019 Jul 24;9(1):10769. doi: 10.1038/s41598-019-46723-6. Sci Rep. 2019. PMID: 31341183 Free PMC article.
The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues.
Spörrer M, Kah D, Gerum RC, Reischl B, Huraskin D, Dessalles CA, Schneider W, Goldmann WH, Herrmann H, Thievessen I, Clemen CS, Friedrich O, Hashemolhosseini S, Schröder R, Fabry B. Spörrer M, et al. Among authors: friedrich o. Neuropathol Appl Neurobiol. 2022 Apr;48(3):e12784. doi: 10.1111/nan.12784. Epub 2021 Dec 10. Neuropathol Appl Neurobiol. 2022. PMID: 34850968
The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.
Völkers M, Weidenhammer C, Herzog N, Qiu G, Spaich K, Wegner FV, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O, Most P. Völkers M, et al. Among authors: friedrich o. Circ Res. 2011 Jan 7;108(1):27-39. doi: 10.1161/CIRCRESAHA.110.225201. Epub 2010 Nov 24. Circ Res. 2011. PMID: 21106943 Free PMC article.
249 results