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Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity.
Kadelka C, Liechti T, Ebner H, Schanz M, Rusert P, Friedrich N, Stiegeler E, Braun DL, Huber M, Scherrer AU, Weber J, Uhr T, Kuster H, Misselwitz B, Cavassini M, Bernasconi E, Hoffmann M, Calmy A, Battegay M, Rauch A, Yerly S, Aubert V, Klimkait T, Böni J, Kouyos RD, Günthard HF, Trkola A; Swiss HIV Cohort Study. Kadelka C, et al. Among authors: friedrich n. J Exp Med. 2018 Jun 4;215(6):1589-1608. doi: 10.1084/jem.20180246. Epub 2018 May 24. J Exp Med. 2018. PMID: 29794117 Free PMC article.
Tracing HIV-1 strains that imprint broadly neutralizing antibody responses.
Kouyos RD, Rusert P, Kadelka C, Huber M, Marzel A, Ebner H, Schanz M, Liechti T, Friedrich N, Braun DL, Scherrer AU, Weber J, Uhr T, Baumann NS, Leemann C, Kuster H, Chave JP, Cavassini M, Bernasconi E, Hoffmann M, Calmy A, Battegay M, Rauch A, Yerly S, Aubert V, Klimkait T, Böni J, Metzner KJ, Günthard HF, Trkola A; Swiss HIV Cohort Study. Kouyos RD, et al. Among authors: friedrich n. Nature. 2018 Sep;561(7723):406-410. doi: 10.1038/s41586-018-0517-0. Epub 2018 Sep 10. Nature. 2018. PMID: 30202088
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization.
Friedrich N, Stiegeler E, Glögl M, Lemmin T, Hansen S, Kadelka C, Wu Y, Ernst P, Maliqi L, Foulkes C, Morin M, Eroglu M, Liechti T, Ivan B, Reinberg T, Schaefer JV, Karakus U, Ursprung S, Mann A, Rusert P, Kouyos RD, Robinson JA, Günthard HF, Plückthun A, Trkola A. Friedrich N, et al. Nat Commun. 2021 Nov 18;12(1):6705. doi: 10.1038/s41467-021-27075-0. Nat Commun. 2021. PMID: 34795280 Free PMC article.
Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.
Glögl M, Friedrich N, Cerutti G, Lemmin T, Kwon YD, Gorman J, Maliqi L, Mittl PRE, Hesselman MC, Schmidt D, Weber J, Foulkes C, Dingens AS, Bylund T, Olia AS, Verardi R, Reinberg T, Baumann NS, Rusert P, Dreier B, Shapiro L, Kwong PD, Plückthun A, Trkola A. Glögl M, et al. Among authors: friedrich n. Nat Struct Mol Biol. 2023 Sep;30(9):1323-1336. doi: 10.1038/s41594-023-01062-z. Epub 2023 Aug 21. Nat Struct Mol Biol. 2023. PMID: 37605043 Free PMC article.
Assessing immunogenicity barriers of the HIV-1 envelope trimer.
Maliqi L, Friedrich N, Glögl M, Schmutz S, Schmidt D, Rusert P, Schanz M, Zaheri M, Pasin C, Niklaus C, Foulkes C, Reinberg T, Dreier B, Abela I, Peterhoff D, Hauser A, Kouyos RD, Günthard HF, van Gils MJ, Sanders RW, Wagner R, Plückthun A, Trkola A. Maliqi L, et al. Among authors: friedrich n. NPJ Vaccines. 2023 Sep 30;8(1):148. doi: 10.1038/s41541-023-00746-3. NPJ Vaccines. 2023. PMID: 37777519 Free PMC article.
345 results