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Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models.
Dejanovic B, Wu T, Tsai MC, Graykowski D, Gandham VD, Rose CM, Bakalarski CE, Ngu H, Wang Y, Pandey S, Rezzonico MG, Friedman BA, Edmonds R, De Mazière A, Rakosi-Schmidt R, Singh T, Klumperman J, Foreman O, Chang MC, Xie L, Sheng M, Hanson JE. Dejanovic B, et al. Among authors: friedman ba. Nat Aging. 2022 Sep;2(9):837-850. doi: 10.1038/s43587-022-00281-1. Epub 2022 Sep 20. Nat Aging. 2022. PMID: 37118504 Free PMC article.
Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses.
Srinivasan K, Friedman BA, Larson JL, Lauffer BE, Goldstein LD, Appling LL, Borneo J, Poon C, Ho T, Cai F, Steiner P, van der Brug MP, Modrusan Z, Kaminker JS, Hansen DV. Srinivasan K, et al. Among authors: friedman ba. Nat Commun. 2016 Apr 21;7:11295. doi: 10.1038/ncomms11295. Nat Commun. 2016. PMID: 27097852 Free PMC article.
Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, Carano RAD, Chih B, Klumperman J, Bakalarski C, Hanson JE, Sheng M. Dejanovic B, et al. Among authors: friedman ba. Neuron. 2018 Dec 19;100(6):1322-1336.e7. doi: 10.1016/j.neuron.2018.10.014. Epub 2018 Nov 1. Neuron. 2018. PMID: 30392797 Free article.
Microglia in Brain Development, Homeostasis, and Neurodegeneration.
Bohlen CJ, Friedman BA, Dejanovic B, Sheng M. Bohlen CJ, et al. Among authors: friedman ba. Annu Rev Genet. 2019 Dec 3;53:263-288. doi: 10.1146/annurev-genet-112618-043515. Epub 2019 Sep 13. Annu Rev Genet. 2019. PMID: 31518519 Review.
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
Meilandt WJ, Ngu H, Gogineni A, Lalehzadeh G, Lee SH, Srinivasan K, Imperio J, Wu T, Weber M, Kruse AJ, Stark KL, Chan P, Kwong M, Modrusan Z, Friedman BA, Elstrott J, Foreman O, Easton A, Sheng M, Hansen DV. Meilandt WJ, et al. Among authors: friedman ba. J Neurosci. 2020 Feb 26;40(9):1956-1974. doi: 10.1523/JNEUROSCI.1871-19.2019. Epub 2020 Jan 24. J Neurosci. 2020. PMID: 31980586 Free PMC article.
128 results