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Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF.
Decaris ML, Schaub JR, Chen C, Cha J, Lee GG, Rexhepaj M, Ho SS, Rao V, Marlow MM, Kotak P, Budi EH, Hooi L, Wu J, Fridlib M, Martin SP, Huang S, Chen M, Muñoz M, Hom TF, Wolters PJ, Desai TJ, Rock F, Leftheris K, Morgans DJ, Lepist EI, Andre P, Lefebvre EA, Turner SM. Decaris ML, et al. Among authors: fridlib m. Respir Res. 2021 Oct 19;22(1):265. doi: 10.1186/s12931-021-01863-0. Respir Res. 2021. PMID: 34666752 Free PMC article.
Blocking macrophage leukotriene b4 prevents endothelial injury and reverses pulmonary hypertension.
Tian W, Jiang X, Tamosiuniene R, Sung YK, Qian J, Dhillon G, Gera L, Farkas L, Rabinovitch M, Zamanian RT, Inayathullah M, Fridlib M, Rajadas J, Peters-Golden M, Voelkel NF, Nicolls MR. Tian W, et al. Among authors: fridlib m. Sci Transl Med. 2013 Aug 28;5(200):200ra117. doi: 10.1126/scitranslmed.3006674. Sci Transl Med. 2013. PMID: 23986401 Free PMC article.
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.
Ventura R, Mordec K, Waszczuk J, Wang Z, Lai J, Fridlib M, Buckley D, Kemble G, Heuer TS. Ventura R, et al. Among authors: fridlib m. EBioMedicine. 2015 Jul 2;2(8):808-24. doi: 10.1016/j.ebiom.2015.06.020. eCollection 2015 Aug. EBioMedicine. 2015. PMID: 26425687 Free PMC article.
FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression.
Heuer TS, Ventura R, Mordec K, Lai J, Fridlib M, Buckley D, Kemble G. Heuer TS, et al. Among authors: fridlib m. EBioMedicine. 2017 Feb;16:51-62. doi: 10.1016/j.ebiom.2016.12.012. Epub 2016 Dec 24. EBioMedicine. 2017. PMID: 28159572 Free PMC article.