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High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses.
Cruz DJ, Koishi AC, Taniguchi JB, Li X, Milan Bonotto R, No JH, Kim KH, Baek S, Kim HY, Windisch MP, Pamplona Mosimann AL, de Borba L, Liuzzi M, Hansen MA, Duarte dos Santos CN, Freitas-Junior LH. Cruz DJ, et al. PLoS Negl Trop Dis. 2013;7(2):e2073. doi: 10.1371/journal.pntd.0002073. Epub 2013 Feb 21. PLoS Negl Trop Dis. 2013. PMID: 23437413 Free PMC article.
Multitarget drug discovery for tuberculosis and other infectious diseases.
Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis RB, Crick DC, Oldfield E. Li K, et al. J Med Chem. 2014 Apr 10;57(7):3126-39. doi: 10.1021/jm500131s. Epub 2014 Apr 1. J Med Chem. 2014. PMID: 24568559 Free PMC article.
Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.
Zhang Y, Zhu W, Liu YL, Wang H, Wang K, Li K, No JH, Ayong L, Gulati A, Pang R, Freitas-Junior L, Morita CT, Old-Field E. Zhang Y, et al. ACS Med Chem Lett. 2013 Apr 11;4(4):423-427. doi: 10.1021/ml4000436. ACS Med Chem Lett. 2013. PMID: 23610597 Free PMC article.
Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander (Salamandra salamandra).
Barros ALAN, Silva VC, Ribeiro-Junior AF, Cardoso MG, Costa SR, Moraes CB, Barbosa CG, Coleone AP, Simões RP, Cabral WF, Falcão RM, Vasconcelos AG, Rocha JA, Arcanjo DDR, Batagin-Neto A, Borges TKS, Gonçalves J, Brand GD, Freitas-Junior LHG, Eaton P, Marani M, Kato MJ, Plácido A, Leite JRSA. Barros ALAN, et al. Among authors: freitas junior lhg. Pharmaceutics. 2024 Jan 29;16(2):190. doi: 10.3390/pharmaceutics16020190. Pharmaceutics. 2024. PMID: 38399250 Free PMC article.
A potential antiviral against COVID-19 obtained from Byrsonima coccolobifolia leaves extract.
Rodrigues CM, Bento CC, Moraes CB, Gomes C, Ioshino RS, Freitas-Junior LH, de Castro Spadari C, Ishida K, Vilegas W, Carvalho JCS, Ferreira MJP, Carbone V, Piacente S, Molina de Angelo R, Honorio KM, Sannomiya M. Rodrigues CM, et al. Among authors: freitas junior lh. Fitoterapia. 2024 Mar;173:105820. doi: 10.1016/j.fitote.2024.105820. Epub 2024 Jan 9. Fitoterapia. 2024. PMID: 38211642
SARS-CoV-2 Spike protein peptides displayed in the Pyrococcus furiosus RAD system preserve epitopes antigenicity, immunogenicity, and virus-neutralizing activity of antibodies.
Cioffi VB, de Castro-Amarante MF, Lulla A, Andreata-Santos R, Cruz MC, Moreno ACR, de Oliveira Silva M, de Miranda Peres B, de Freitas Junior LHG, Moraes CB, Durigon EL, Gordon NC, Hyvönen M, de Souza Ferreira LC, Balan A. Cioffi VB, et al. Among authors: de freitas junior lhg. Sci Rep. 2023 Oct 5;13(1):16821. doi: 10.1038/s41598-023-43720-8. Sci Rep. 2023. PMID: 37798298 Free PMC article.
72 results