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Saraf-dependent activation of mTORC1 regulates cardiac growth.
Sanlialp A, Schumacher D, Kiper L, Varma E, Riechert E, Ho TC, Hofmann C, Kmietczyk V, Zimmermann F, Dlugosz S, Wirth A, Gorska AA, Burghaus J, Camacho Londoño JE, Katus HA, Doroudgar S, Freichel M, Völkers M. Sanlialp A, et al. Among authors: freichel m. J Mol Cell Cardiol. 2020 Apr;141:30-42. doi: 10.1016/j.yjmcc.2020.03.004. Epub 2020 Mar 13. J Mol Cell Cardiol. 2020. PMID: 32173353
Increased β-adrenergic inotropy in ventricular myocardium from Trpm4-/- mice.
Mathar I, Kecskes M, Van der Mieren G, Jacobs G, Camacho Londoño JE, Uhl S, Flockerzi V, Voets T, Freichel M, Nilius B, Herijgers P, Vennekens R. Mathar I, et al. Among authors: freichel m. Circ Res. 2014 Jan 17;114(2):283-94. doi: 10.1161/CIRCRESAHA.114.302835. Epub 2013 Nov 13. Circ Res. 2014. PMID: 24226423
TRPC4- and TRPC4-containing channels.
Freichel M, Tsvilovskyy V, Camacho-Londoño JE. Freichel M, et al. Handb Exp Pharmacol. 2014;222:85-128. doi: 10.1007/978-3-642-54215-2_5. Handb Exp Pharmacol. 2014. PMID: 24756704 Review.
A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling.
Camacho Londoño JE, Tian Q, Hammer K, Schröder L, Camacho Londoño J, Reil JC, He T, Oberhofer M, Mannebach S, Mathar I, Philipp SE, Tabellion W, Schweda F, Dietrich A, Kaestner L, Laufs U, Birnbaumer L, Flockerzi V, Freichel M, Lipp P. Camacho Londoño JE, et al. Among authors: freichel m. Eur Heart J. 2015 Sep 1;36(33):2257-66. doi: 10.1093/eurheartj/ehv250. Epub 2015 Jun 11. Eur Heart J. 2015. PMID: 26069213 Free PMC article.
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.
Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J. Lehmann LH, et al. Among authors: freichel m. Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452. Epub 2017 Dec 11. Nat Med. 2018. PMID: 29227474
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.
Sachdeva R, Schlotterer A, Schumacher D, Matka C, Mathar I, Dietrich N, Medert R, Kriebs U, Lin J, Nawroth P, Birnbaumer L, Fleming T, Hammes HP, Freichel M. Sachdeva R, et al. Among authors: freichel m. Mol Metab. 2018 Mar;9:156-167. doi: 10.1016/j.molmet.2018.01.003. Epub 2018 Jan 5. Mol Metab. 2018. PMID: 29373286 Free PMC article.
146 results