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TRPC4- and TRPC4-containing channels.
Freichel M, Tsvilovskyy V, Camacho-Londoño JE. Freichel M, et al. Handb Exp Pharmacol. 2014;222:85-128. doi: 10.1007/978-3-642-54215-2_5. Handb Exp Pharmacol. 2014. PMID: 24756704 Review.
TRPC4 and TRPC4-deficient mice.
Freichel M, Philipp S, Cavalié A, Flockerzi V. Freichel M, et al. Novartis Found Symp. 2004;258:189-99; discussion 199-203, 263-6. Novartis Found Symp. 2004. PMID: 15104183 Review.
Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice.
Mathar I, Vennekens R, Meissner M, Kees F, Van der Mieren G, Camacho Londoño JE, Uhl S, Voets T, Hummel B, van den Bergh A, Herijgers P, Nilius B, Flockerzi V, Schweda F, Freichel M. Mathar I, et al. Among authors: freichel m. J Clin Invest. 2010 Sep;120(9):3267-79. doi: 10.1172/JCI41348. Epub 2010 Aug 2. J Clin Invest. 2010. PMID: 20679729 Free PMC article.
Male fertility depends on Ca²+ absorption by TRPV6 in epididymal epithelia.
Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Vennekens R, Wissenbach U, Middendorff R, Flockerzi V, Freichel M. Weissgerber P, et al. Among authors: freichel m. Sci Signal. 2011 May 3;4(171):ra27. doi: 10.1126/scisignal.2001791. Sci Signal. 2011. PMID: 21540454
Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation.
Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Mannebach S, Wissenbach U, Vennekens R, Middendorff R, Flockerzi V, Freichel M. Weissgerber P, et al. Among authors: freichel m. J Biol Chem. 2012 May 25;287(22):17930-41. doi: 10.1074/jbc.M111.328286. Epub 2012 Mar 15. J Biol Chem. 2012. PMID: 22427671 Free PMC article.
., Vennekens, R., Wissenbach, U., Middendorff, R., Flockerzi, V., and Freichel, M. (2011) Sci. Signal. 4, ra27). It is known from other cation channels that introducing pore mutations even if they largely affect their conductivity and permeability can evoke consider …
., Vennekens, R., Wissenbach, U., Middendorff, R., Flockerzi, V., and Freichel, M. (2011) Sci. Signal. 4, ra27). It is known f …
146 results