Frei E - Search Results

1

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.

Milichovský J, Bárta F, Schmeiser HH, Arlt VM, Frei E, Stiborová M, Martínek V. Milichovský J, et al. Among authors: frei e. Int J Mol Sci. 2016 Feb 5;17(2):213. doi: 10.3390/ijms17020213. Int J Mol Sci. 2016. PMID: 26861298 Free PMC article.

2

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

Stiborová M, Frei E, Hodek P, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Int J Cancer. 2005 Jan 10;113(2):189-97. doi: 10.1002/ijc.20564. Int J Cancer. 2005. PMID: 15386410 Free article.

3

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen.

Stiborová M, Sopko B, Hodek P, Frei E, Schmeiser HH, Hudecek J. Stiborová M, et al. Among authors: frei e. Cancer Lett. 2005 Nov 18;229(2):193-204. doi: 10.1016/j.canlet.2005.06.038. Epub 2005 Aug 24. Cancer Lett. 2005. PMID: 16125300

4

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

Stiborová M, Frei E, Arlt VM, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Mutat Res. 2008 Jan-Feb;658(1-2):55-67. doi: 10.1016/j.mrrev.2007.07.003. Epub 2007 Aug 6. Mutat Res. 2008. PMID: 17851120 Free article. Review.

5

Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid.

Sistkova J, Hudecek J, Hodek P, Frei E, Schmeiser HH, Stiborova M. Sistkova J, et al. Among authors: frei e. Neuro Endocrinol Lett. 2008 Oct;29(5):733-7. Neuro Endocrinol Lett. 2008. PMID: 18987598

6

The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers.

Stiborova M, Frei E, Arlt VM, Schmeiser HH. Stiborova M, et al. Among authors: frei e. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):5-11. doi: 10.5507/bp.2009.001. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009. PMID: 19365519 Free article. Review.

7

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

Levová K, Moserová M, Kotrbová V, Sulc M, Henderson CJ, Wolf CR, Phillips DH, Frei E, Schmeiser HH, Mares J, Arlt VM, Stiborová M. Levová K, et al. Among authors: frei e. Toxicol Sci. 2011 May;121(1):43-56. doi: 10.1093/toxsci/kfr050. Epub 2011 Feb 28. Toxicol Sci. 2011. PMID: 21362632 Free article.

8

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases.

Stiborová M, Mareš J, Frei E, Arlt VM, Martínek V, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Environ Mol Mutagen. 2011 Jul;52(6):448-59. doi: 10.1002/em.20642. Epub 2011 Mar 2. Environ Mol Mutagen. 2011. PMID: 21370283

9

Cytochrome b(5) shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy.

Kotrbová V, Mrázová B, Moserová M, Martínek V, Hodek P, Hudeček J, Frei E, Stiborová M. Kotrbová V, et al. Among authors: frei e. Biochem Pharmacol. 2011 Sep 15;82(6):669-80. doi: 10.1016/j.bcp.2011.06.003. Epub 2011 Jun 13. Biochem Pharmacol. 2011. PMID: 21683692

10

Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

Arlt VM, Levová K, Bárta F, Shi Z, Evans JD, Frei E, Schmeiser HH, Nebert DW, Phillips DH, Stiborová M. Arlt VM, et al. Among authors: frei e. Chem Res Toxicol. 2011 Oct 17;24(10):1710-9. doi: 10.1021/tx200259y. Epub 2011 Sep 29. Chem Res Toxicol. 2011. PMID: 21932800

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